一种新的 Oxoaporphine 和 Liriodenine 从 Polyalthia bullata King 的根中提取并具有抗神经母细胞瘤的潜力

IF 0.7 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Sains Malaysiana Pub Date : 2024-02-29 DOI:10.17576/jsm-2024-5302-10

P. Primus, Carol Hsin-Yi Wu, Chai-Lin Kao, Y. Choo

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引用次数: 0

摘要

Polyalthia bullata King 的根中除了之前发现的六种化合物外，还发现了一种名为 5-甲基lliridine（1）的新化合物。这些已知化合物包括 liriodenine (2)、11-甲氧基iriodenine (3)、lysicamine (4)、onychine (5)、5-羟基-6-甲氧基onychine (6) 和 8-甲氧基yeupolauridine (7)。化合物 1-7 的结构是通过光谱分析确定的。Liriodenine（2）能在 24 小时内将 N2A 癌细胞的存活率降低至 22%，显示出其作为抗神经母细胞瘤药物的潜力。分子对接结果还表明，氧代阿扑啡（1-4）具有作为蛋白激酶抑制剂的潜力。这些发现凸显了牛肝菌成分在治疗癌症（尤其是神经母细胞瘤）方面的潜力，并有助于了解其药用特性。

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A New Oxoaporphine and Liriodenine's Anti-Neuroblastoma Potential from the Roots of Polyalthia bullata King

Polyalthia bullata King’s root yielded a new compound named 5-methylliridine (1) in addition to six previously identified compounds. These known compounds include liriodenine (2), 11-methoxyliriodenine (3), lysicamine (4), onychine (5), 5-hydroxy-6-methoxyonychine (6), and 8-methoxyeupolauridine (7). The structures of compounds 1-7 were determined through spectroscopic analysis. Liriodenine (2) exhibited a remarkable ability to decrease the cell viability of cancerous N2A cells to 22% within a 24 h timeframe, indicating its potential as an anti-neuroblastoma agent. Molecular docking results additionally suggested that oxoaporphines (1-4) have the potential to act as inhibitors of protein kinases. These findings highlight the therapeutic potential of P. bullata constituents in cancer treatment, particularly neuroblastoma, and contribute to understanding its medicinal properties.

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来源期刊

Sains Malaysiana MULTIDISCIPLINARY SCIENCES-

CiteScore

1.60

自引率

12.50%

发文量

196

审稿时长

3-6 weeks

期刊介绍： Sains Malaysiana is a refereed journal committed to the advancement of scholarly knowledge and research findings of the several branches of science and technology. It contains articles on Earth Sciences, Health Sciences, Life Sciences, Mathematical Sciences and Physical Sciences. The journal publishes articles, reviews, and research notes whose content and approach are of interest to a wide range of scholars. Sains Malaysiana is published by the UKM Press an its autonomous Editorial Board are drawn from the Faculty of Science and Technology, Universiti Kebangsaan Malaysia. In addition, distinguished scholars from local and foreign universities are appointed to serve as advisory board members and referees.