组织工程方法在肌腱连接处修复和康复方面的进展

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Kariman A. Shama , Mariah A. Turner , Harrison B. Broadaway , Elizabeth L. Aikman , Whitney L. Stoppel , Brittany L. Taylor
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引用次数: 0

摘要

肌腱连接处(MTJ)是肌肉和肌腱之间的桥梁,但其相对于肌纤维的高硬度使该组织容易因偏心负荷差异而受伤。MTJ 组织的再生能力有限,手术后可能出现疤痕和再损伤,因此需要能增强细胞相互作用、恢复机械性能和支持组织康复的辅助疗法。本综述探讨了利用生物材料支架和细胞化材料模拟结构和功能来改造 MTJ 的各种方法。虽然生物仿生材料前景广阔,但由于界面的复杂性以及不同患者和部位的特定结构-功能特征,挑战依然存在,因此有必要开展进一步的研究来弥补这些差距。本综述还强调了研究 MTJ 损伤对女性健康和颅面重建的重要性。此外,工程化 MTJ 模型为研究创伤和退化提供了多功能平台,从而为推动多个领域的研究、阐明组织界面的相互作用以及塑造 MTJ 康复的未来提供了潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in tissue engineering approaches for repairing and rehabilitating the myotendinous junction

The myotendinous junction (MTJ) acts as a bridge between muscle and tendon; yet its high stiffness relative to muscle fibers renders the tissue susceptible to injuries due to eccentric loading disparities. The limited regenerative capacity of MTJ tissue and potential for postsurgical scarring and reinjury necessitates complementary therapeutics that can enhance cellular interactions, restore mechanical properties, and support tissue rehabilitation.

This review explores various approaches to engineer the MTJ utilizing biomaterial scaffolds and cellularized materials that mimic structure and function. While biomimetic materials show promise, challenges remain due to the interface's complexity and differing patient- and location-specific structure–function characteristics, necessitating further research to address these gaps. This review also highlights the importance of studying MTJ injuries in women's health and craniofacial reconstruction. Furthermore, engineered MTJ models provide versatile platforms for investigating trauma and degeneration, thus offering potential for advancing research across multiple fields, shedding light on interactions at tissue interfaces, and shaping the future of MTJ rehabilitation.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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