木槿对 6-OHDA 诱发的帕金森病大鼠的神经保护活性

Kashinath Akki, Mallappa Shalavadi , VM Chandrashekhar , Shubham Teli , Lingaraj Anawal , Bhushan Khombare
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引用次数: 0

摘要

材料与方法通过诱导 SD 大鼠纹状体 6-OHDA 损伤,对帕金森病进行神经保护。对大鼠进行了行为学研究,如行为评估、肌肉协调、运动活动和空场活动,并对酶和非酶抗氧化剂水平进行了评估。结果与对照组相比,木槿林的水醇提取物对帕金森氏症具有神经保护活性,在行为研究中表现出积极的反应,包括脂质过氧化物(LPO)显著降低,超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽(GSH)和总硫醇水平增加。与对照组相比,提取物处理组的纹状体梗死面积明显减少。组织病理学研究也显示了提取物的显著效果。在大鼠模型中显示出对帕金森病的神经保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuroprotective activity of Hibiscus abelmoschus Linn. against 6-OHDA induced Parkinson’s disease in rats

Aim

To evaluate the neuroprotective activity of Hibiscus abelmoschus Linn. against Parkinson’s Disease in rat model.

Materials and methods

Neuroprotective activity was carried out on Parkinson’s Disease by inducing striatal 6-OHDA lesions in SD rats. The behavioral studies such as behavioral assessment, muscular coordination, locomotor activity, and open field were performed along with enzymatic and non-enzymatic antioxidants level were estimated. Striatal infarction area and histopathological studies were also performed.

Results

The hydroalcohol extract of Hibiscus abelmoschus Linn. showed neuroprotective activity against Parkinson’s Disease by positive response in behavioral studies including significant decrease in lipid peroxidation (LPO) and increase in superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiol levels in extract treated groups as compared to control group. Striatal infarction area was significantly reduced in extract treated groups as compared to control group. Histopathological studies also shows a significant effect of extract.

Conclusion

The hydroalcohol extract of Hibiscus abelmoschus Linn. Showed neuroprotective against Parkinson’s Disease in rat model.

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