{"title":"木槿对 6-OHDA 诱发的帕金森病大鼠的神经保护活性","authors":"Kashinath Akki, Mallappa Shalavadi , VM Chandrashekhar , Shubham Teli , Lingaraj Anawal , Bhushan Khombare","doi":"10.1016/j.prenap.2024.100027","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>To evaluate the neuroprotective activity of <em>Hibiscus abelmoschus</em> Linn. against Parkinson’s Disease in rat model.</p></div><div><h3>Materials and methods</h3><p>Neuroprotective activity was carried out on Parkinson’s Disease by inducing striatal 6-OHDA lesions in SD rats. The behavioral studies such as behavioral assessment, muscular coordination, locomotor activity, and open field were performed along with enzymatic and non-enzymatic antioxidants level were estimated. Striatal infarction area and histopathological studies were also performed.</p></div><div><h3>Results</h3><p>The hydroalcohol extract of <em>Hibiscus abelmoschus</em> Linn. showed neuroprotective activity against Parkinson’s Disease by positive response in behavioral studies including significant decrease in lipid peroxidation (LPO) and increase in superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiol levels in extract treated groups as compared to control group. Striatal infarction area was significantly reduced in extract treated groups as compared to control group. Histopathological studies also shows a significant effect of extract.</p></div><div><h3>Conclusion</h3><p>The hydroalcohol extract of <em>Hibiscus abelmoschus</em> Linn. Showed neuroprotective against Parkinson’s Disease in rat model.</p></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"3 ","pages":"Article 100027"},"PeriodicalIF":0.0000,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuroprotective activity of Hibiscus abelmoschus Linn. against 6-OHDA induced Parkinson’s disease in rats\",\"authors\":\"Kashinath Akki, Mallappa Shalavadi , VM Chandrashekhar , Shubham Teli , Lingaraj Anawal , Bhushan Khombare\",\"doi\":\"10.1016/j.prenap.2024.100027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><p>To evaluate the neuroprotective activity of <em>Hibiscus abelmoschus</em> Linn. against Parkinson’s Disease in rat model.</p></div><div><h3>Materials and methods</h3><p>Neuroprotective activity was carried out on Parkinson’s Disease by inducing striatal 6-OHDA lesions in SD rats. The behavioral studies such as behavioral assessment, muscular coordination, locomotor activity, and open field were performed along with enzymatic and non-enzymatic antioxidants level were estimated. Striatal infarction area and histopathological studies were also performed.</p></div><div><h3>Results</h3><p>The hydroalcohol extract of <em>Hibiscus abelmoschus</em> Linn. showed neuroprotective activity against Parkinson’s Disease by positive response in behavioral studies including significant decrease in lipid peroxidation (LPO) and increase in superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiol levels in extract treated groups as compared to control group. Striatal infarction area was significantly reduced in extract treated groups as compared to control group. Histopathological studies also shows a significant effect of extract.</p></div><div><h3>Conclusion</h3><p>The hydroalcohol extract of <em>Hibiscus abelmoschus</em> Linn. Showed neuroprotective against Parkinson’s Disease in rat model.</p></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"3 \",\"pages\":\"Article 100027\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950199724000156\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199724000156","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Neuroprotective activity of Hibiscus abelmoschus Linn. against 6-OHDA induced Parkinson’s disease in rats
Aim
To evaluate the neuroprotective activity of Hibiscus abelmoschus Linn. against Parkinson’s Disease in rat model.
Materials and methods
Neuroprotective activity was carried out on Parkinson’s Disease by inducing striatal 6-OHDA lesions in SD rats. The behavioral studies such as behavioral assessment, muscular coordination, locomotor activity, and open field were performed along with enzymatic and non-enzymatic antioxidants level were estimated. Striatal infarction area and histopathological studies were also performed.
Results
The hydroalcohol extract of Hibiscus abelmoschus Linn. showed neuroprotective activity against Parkinson’s Disease by positive response in behavioral studies including significant decrease in lipid peroxidation (LPO) and increase in superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiol levels in extract treated groups as compared to control group. Striatal infarction area was significantly reduced in extract treated groups as compared to control group. Histopathological studies also shows a significant effect of extract.
Conclusion
The hydroalcohol extract of Hibiscus abelmoschus Linn. Showed neuroprotective against Parkinson’s Disease in rat model.