Dr. Tharwat Mohy El-Dine, Matthieu Lavayssiere, Dr. Hélène Adihou, Prof. Gilles Subra, Dr. Thomas-Xavier Métro, Dr. Olivier Ludemann-Hombourger, Dr. Frédéric Lamaty
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Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame.
The solventless synthesis of peptides from unactivated amino acids was optimized in a twin-screw extruder (TSE). The general method enabled the preparation of dipeptides and tripeptides with no epimerization. This flow mechanochemistry approach was applied to the synthesis of aspartame, a synthetic dipeptide, prepared in a continuous mode on large scale and with high productivity.
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