解码寿命的秘密:性腺在秀丽隐杆线虫衰老中的作用

Andre Pires da Silva, Rhianne Kelleher, Luke Reynoldson
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引用次数: 0

摘要

性腺已成为了解 elegans 衰老的核心器官,因为去除生殖系中增殖的干细胞可显著延长寿命。同样,当幼虫晚期的饥饿导致生殖系干细胞静止时,成年线虫会进入生殖休眠期,从而延长寿命。本综述总结了在确定性腺介导的寿命延长机制方面的最新进展,包括与其他线虫的比较以及脂质信号转导和转录变化的作用。鉴于性腺也介导其他无脊椎动物和脊椎动物的寿命调节,阐明其背后的机制可能有助于对衰老的机制和进化有新的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decoding lifespan secrets: the role of the gonad in Caenorhabditis elegans aging
The gonad has become a central organ for understanding aging in C. elegans, as removing the proliferating stem cells in the germline results in significant lifespan extension. Similarly, when starvation in late larval stages leads to the quiescence of germline stem cells the adult nematode enters reproductive diapause, associated with an extended lifespan. This review summarizes recent advancements in identifying the mechanisms behind gonad-mediated lifespan extension, including comparisons with other nematodes and the role of lipid signaling and transcriptional changes. Given that the gonad also mediates lifespan regulation in other invertebrates and vertebrates, elucidating the underlying mechanisms may help to gain new insights into the mechanisms and evolution of aging.
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