易倍申:治疗耐多药微生物感染的前景看好的再利用药物

Q3 Immunology and Microbiology
Agostinho Alves de Lima e Silva, André Rio-Tinto
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引用次数: 0

摘要

细菌的多重耐药性是一个迅速增长的全球现象。不同细菌病原体中都出现了新的抗药性机制,甚至威胁到常见传染病的有效治疗。在与生物膜相关的感染中,这一问题更加严重,因为除了病原体的多重耐药性外,生物膜还提供了一道屏障,阻止抗菌药物进入。有几种 "非抗生素 "药物具有抗菌活性,尽管这并不是它们的主要治疗目的。然而,由于急需开发有效的抗菌药物来治疗由具有多重耐药性的病原体引起的疾病,对 "非抗生素 "药物的研究日益增多,通过所谓的药物重新定位或重新使用来提供替代疗法。现有药物的新用途前景具有减少开发新化合物所需的时间和精力的优势。此外,许多药物在毒性和药代动力学/药效学特性方面已经有了很好的表征。Ebselen 已显示出作为抗菌药物再利用的前景。它是一种人工合成的有机硒,具有抗炎、抗氧化和细胞保护活性。使用依布硒的一个非常有吸引力的因素是,除了具有强大的抗菌活性外,它对微生物病原体的最小抑制浓度也非常低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ebselen: A Promising Repurposing Drug to Treat Infections Caused by Multidrug-Resistant Microorganisms
Bacterial multiresistance to drugs is a rapidly growing global phenomenon. New resistance mechanisms have been described in different bacterial pathogens, threatening the effective treatment of even common infectious diseases. The problem worsens in infections associated with biofilms because, in addition to the pathogen’s multiresistance, the biofilm provides a barrier that prevents antimicrobial access. Several “non-antibiotic” drugs have antimicrobial activity, even though it is not their primary therapeutic purpose. However, due to the urgent need to develop effective antimicrobials to treat diseases caused by multidrug-resistant pathogens, there has been an increase in research into “non-antibiotic” drugs to offer an alternative therapy through the so-called drug repositioning or repurposing. The prospect of new uses for existing drugs has the advantage of reducing the time and effort required to develop new compounds. Moreover, many drugs are already well characterized regarding toxicity and pharmacokinetic/pharmacodynamic properties. Ebselen has shown promise for use as a repurposing drug for antimicrobial purposes. It is a synthetic organoselenium with anti-inflammatory, antioxidant, and cytoprotective activity. A very attractive factor for using ebselen is that, in addition to potent antimicrobial activity, its minimum inhibitory concentration is very low for microbial pathogens.
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
51
审稿时长
18 weeks
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