Amal Belakredar, F. Boudou, Narimane Taibi, K. Hachem, Yasmina Benabdesslem
{"title":"Anvillea radiata 水提取物对四氯化碳诱导的大鼠肝损伤的保护作用","authors":"Amal Belakredar, F. Boudou, Narimane Taibi, K. Hachem, Yasmina Benabdesslem","doi":"10.7546/crabs.2024.03.06","DOIUrl":null,"url":null,"abstract":"The present study aimed to assess the hepatoprotective property of Anvillea radiata aqueous extract (AAE) against carbon tetrachloride (CCl4)-induced liver injury in rats. Twenty rats were divided into four groups: the control group received no treatment; the second group received a 1 ml dose of CCl4 (30%) orally; the third received a 1 ml dose of CCl4 (30%) orally and AAE at a dosage of 40 mg per kilogram of body weight; the fourth group received AAE alone at the same dose. The results indicated that co-exposure to CCl4 and AAE significantly improved hepatic enzyme markers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), compared to the CCl4-exposed group. Histological examinations demonstrated that AAE preserved the normal architecture of hepatocytes. In conclusion, Anvillea radiata exhibits notable hepatoprotective property against CCl4-induced toxicity in rats.","PeriodicalId":104760,"journal":{"name":"Proceedings of the Bulgarian Academy of Sciences","volume":"13 10","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hepatoprotective Effect of Anvillea radiata Aqueous Extract against Carbon Tetrachloride-Induced Injury in Rats\",\"authors\":\"Amal Belakredar, F. Boudou, Narimane Taibi, K. Hachem, Yasmina Benabdesslem\",\"doi\":\"10.7546/crabs.2024.03.06\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present study aimed to assess the hepatoprotective property of Anvillea radiata aqueous extract (AAE) against carbon tetrachloride (CCl4)-induced liver injury in rats. Twenty rats were divided into four groups: the control group received no treatment; the second group received a 1 ml dose of CCl4 (30%) orally; the third received a 1 ml dose of CCl4 (30%) orally and AAE at a dosage of 40 mg per kilogram of body weight; the fourth group received AAE alone at the same dose. The results indicated that co-exposure to CCl4 and AAE significantly improved hepatic enzyme markers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), compared to the CCl4-exposed group. Histological examinations demonstrated that AAE preserved the normal architecture of hepatocytes. In conclusion, Anvillea radiata exhibits notable hepatoprotective property against CCl4-induced toxicity in rats.\",\"PeriodicalId\":104760,\"journal\":{\"name\":\"Proceedings of the Bulgarian Academy of Sciences\",\"volume\":\"13 10\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Bulgarian Academy of Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7546/crabs.2024.03.06\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Bulgarian Academy of Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7546/crabs.2024.03.06","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hepatoprotective Effect of Anvillea radiata Aqueous Extract against Carbon Tetrachloride-Induced Injury in Rats
The present study aimed to assess the hepatoprotective property of Anvillea radiata aqueous extract (AAE) against carbon tetrachloride (CCl4)-induced liver injury in rats. Twenty rats were divided into four groups: the control group received no treatment; the second group received a 1 ml dose of CCl4 (30%) orally; the third received a 1 ml dose of CCl4 (30%) orally and AAE at a dosage of 40 mg per kilogram of body weight; the fourth group received AAE alone at the same dose. The results indicated that co-exposure to CCl4 and AAE significantly improved hepatic enzyme markers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), compared to the CCl4-exposed group. Histological examinations demonstrated that AAE preserved the normal architecture of hepatocytes. In conclusion, Anvillea radiata exhibits notable hepatoprotective property against CCl4-induced toxicity in rats.
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