人类肠道神经解剖学:人类“肠神经系统”中神经成分和神经递质多样性定量分析的方法学。

Basic and applied histochemistry Pub Date : 1988-01-01
G L Ferri
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引用次数: 0

摘要

在被忽视了几十年之后,“肠道神经系统”最近重新引起了研究者的注意。事实上,各种各样的研究,例如从肠道中分离出许多神经肽的研究,随后在整个神经系统中得到证实,促进了现代神经科学的重大进步。然而,尽管有大量的动物研究和大量的人体研究,关于人类“肠神经系统”的可用信息相对较少。我们认为,这种信息的缺乏主要是由于没有适当的技术,因此我们开始并发展了一种新的综合方法。通过这种方式,可以对沿肠道的神经结构和递质状态进行点对点的定量分析,也可以对胃肠道壁本身的各种功能异质性成分进行定量分析。在一般性介绍之后,本审查的目的是总结这种方法,并以技术附录的形式增加一些应用的说明性例子和面向实际的使用准则。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human gut neuroanatomy: methodology for a quantitative analysis of nerve elements and neurotransmitter diversity in the human "enteric nervous system".

After a few decad of neglect, the "enteric nervous system" has recently regained the attention of investigators. Indeed, various studies, such as those which led to the isolation from the gut of a number of neuropeptides, subsequently demonstrated throughout the nervous system, have prompted major advancements of modern neuroscience. In spite of a wealth of animal investigations and a number of human studies, however, available information concerning the human "enteric nervous system" is comparatively sparse. In the opinion that such lack of information was largely due to unavailability of appropriate techniques, we have initiated and developed a new comprehensive methodology. This way, a quantitative analysis was made possible of both nerve structure and transmitter status, point-to-point along the gut, as well as within the various, functionally heterogeneous components of the gastrointestinal wall itself. After a general introduction, the present review is intended to summarize such methodology, with the addition of a few illustrative examples of application and a practically-oriented guideline to its use, in the form of technical appendix.

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