{"title":"人类疾病中的外周辅助性 T 细胞","authors":"Xueyang Zou , Feifei Huo , Lulu Sun , Jing Huang","doi":"10.1016/j.jaut.2024.103218","DOIUrl":null,"url":null,"abstract":"<div><p>Peripheral helper T cells (Tph) are a specialized subset of CD4<sup>+</sup> T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cytokines, and discuss its B cell help functions. Tph cells also have roles in a wide range of human diseases, including autoimmune diseases, infectious diseases, malignancies etc. Therefore, there is a strong interest in targeting Tph cells to improve treat strategies of human diseases.</p></div>","PeriodicalId":15245,"journal":{"name":"Journal of autoimmunity","volume":"145 ","pages":"Article 103218"},"PeriodicalIF":7.9000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0896841124000520/pdfft?md5=343e9e9aaf7c920a9ca01f2c17b0a8ea&pid=1-s2.0-S0896841124000520-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Peripheral helper T cells in human diseases\",\"authors\":\"Xueyang Zou , Feifei Huo , Lulu Sun , Jing Huang\",\"doi\":\"10.1016/j.jaut.2024.103218\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Peripheral helper T cells (Tph) are a specialized subset of CD4<sup>+</sup> T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cytokines, and discuss its B cell help functions. Tph cells also have roles in a wide range of human diseases, including autoimmune diseases, infectious diseases, malignancies etc. Therefore, there is a strong interest in targeting Tph cells to improve treat strategies of human diseases.</p></div>\",\"PeriodicalId\":15245,\"journal\":{\"name\":\"Journal of autoimmunity\",\"volume\":\"145 \",\"pages\":\"Article 103218\"},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2024-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0896841124000520/pdfft?md5=343e9e9aaf7c920a9ca01f2c17b0a8ea&pid=1-s2.0-S0896841124000520-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of autoimmunity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0896841124000520\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of autoimmunity","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0896841124000520","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
外周辅助 T 细胞（Tph）是 CD4+ T 细胞的一个特化亚群，具有帮助 B 细胞和诱导抗体产生的能力。虽然 Tph 细胞通常位于外周血中的异位淋巴样结构（ELS）中，但也能在外周血中发现。Tph细胞的异常增殖和功能常见于疾病患者。在这篇综述中，我们将首先总结 Tph 细胞的生物学特征，如表面分子、转录因子和细胞因子的表达，并讨论其 B 细胞帮助功能。Tph 细胞还在多种人类疾病中发挥作用，包括自身免疫性疾病、传染病、恶性肿瘤等。因此，人们对靶向 Tph 细胞以改善人类疾病的治疗策略产生了浓厚的兴趣。
Peripheral helper T cells (Tph) are a specialized subset of CD4+ T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cytokines, and discuss its B cell help functions. Tph cells also have roles in a wide range of human diseases, including autoimmune diseases, infectious diseases, malignancies etc. Therefore, there is a strong interest in targeting Tph cells to improve treat strategies of human diseases.
期刊介绍：
The Journal of Autoimmunity serves as the primary publication for research on various facets of autoimmunity. These include topics such as the mechanism of self-recognition, regulation of autoimmune responses, experimental autoimmune diseases, diagnostic tests for autoantibodies, as well as the epidemiology, pathophysiology, and treatment of autoimmune diseases. While the journal covers a wide range of subjects, it emphasizes papers exploring the genetic, molecular biology, and cellular aspects of the field.
The Journal of Translational Autoimmunity, on the other hand, is a subsidiary journal of the Journal of Autoimmunity. It focuses specifically on translating scientific discoveries in autoimmunity into clinical applications and practical solutions. By highlighting research that bridges the gap between basic science and clinical practice, the Journal of Translational Autoimmunity aims to advance the understanding and treatment of autoimmune diseases.
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