Jung-Hoon Park, Ji Won Kim, Dae Sung Ryu, Hyeonseung Lee, Hee Kyong Na, Jin Hee Noh, Do Hoon Kim, Sanghee Lee, Kun Na, Hwoon-Yong Jung
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引用次数: 0
摘要
研究目的本研究旨在探讨使用氯素 e6（Ce6）嵌入式胃内饱腹感诱导装置（ISD）反复进行光动力疗法（PDT）以保持对幼年猪肥胖症治疗效果的有效性和安全性：方法：用浸渍法制作了嵌入 Ce6 的 ISD。将 12 头猪分为四组，每组 3 头，分别给予对照组、单次组、双周组或每周组 PDT。通过比较光毒性、内窥镜检查、透视检查、激素和体重变化以及组织学检查的结果来评估治疗效果：结果：与对照组相比，PDT 治疗猪的总增重百分比显著下降（均为 p 结论：PDT 治疗猪的总增重百分比显著低于对照组（均为 p 结论：PDT 治疗猪的总增重百分比显著低于对照组（均为 p）：重复和定期的光动力疗法在技术上是可行和安全的，并成功地保持了对肥胖症的治疗效果，同时消除了猪的留置时间并减少了与 ISD 相关的并发症。
Repeated photodynamic therapy using a chlorin e6-embedded device to prolong the therapeutic effects on obesity
Objective
This study aimed to investigate the efficacy and safety of repeated photodynamic therapy (PDT) with a chlorin e6 (Ce6)-embedded intragastric satiety-inducing device (ISD) to maintain therapeutic effects of obesity in a juvenile pig.
Methods
The Ce6-embedded ISD was fabricated with a dipping method. Twelve pigs were divided into four groups of three and were administered control, single, biweekly, or weekly PDT, respectively. The therapeutic effects were assessed by comparing the results of phototoxicity, endoscopy, fluoroscopy, hormone and weight changes, and histological examination.
Results
The percentage of total body weight gain was significantly suppressed in PDT-treated pigs compared with control pigs (all p < 0.001). This suppression persisted in the repeated PDT groups, but percentage of total body weight gain gradually increased when PDT was stopped. Ghrelin levels in the PDT-treated groups were significantly lower and leptin levels were significantly higher than those in the control group (all p < 0.05). Inflammatory cell infiltration, collagen, TUNEL, and anti-ghrelin-positive deposition in the weekly group were significantly higher than those in the control, single, and biweekly groups (all p < 0.01).
Conclusions
Repeated and periodic PDT was technically feasible and safe and successfully maintained the therapeutic effects against obesity while eliminating the indwelling time and reducing ISD-related complications in pigs.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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