心血管二级预防中的多丸策略。

IF 3.1 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Current Cardiology Reports Pub Date : 2024-05-01 Epub Date: 2024-04-01 DOI:10.1007/s11886-024-02046-1
Alan De la Rosa, Kedzie Arrington, Rohan Desai, Prakrati C Acharya
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引用次数: 0

摘要

审查目的:多药丸策略最初是为了提高服药依从性而开发的,在多项临床试验中,该策略在改善基线收缩压和胆固醇水平方面显示出了疗效。然而,多药丸改善主要心血管事件(MACE)结果的长期临床影响仍不确定:最新研究结果:最近进行的长期随访试验(包括少数群体和社会经济地位较低的人群)显示,在二级预防重大心血管事件方面,多效丸的疗效并不差,不良反应率也没有差异。虽然多药丸策略最初是为了提高心血管并发症指导性医疗疗法(GDMT)的依从性,但该策略在 MACE 二级预防方面的效果已超过了标准医疗疗法。研究还显示,服务不足人群的服药依从性也有所提高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polypill Strategy in Secondary Cardiovascular Prevention.

Purpose of review: The polypill strategy, originally developed to improve medication adherence, has demonstrated efficacy in improving baseline systolic blood pressures and cholesterol levels in multiple clinical trials. However, the long-term clinical impact of improved major cardiovascular events (MACE) outcomes by the polypill remains uncertain.

Recent findings: Recent trials with long-term follow-up, which included minority groups and people with low socioeconomic status, have shown non-inferiority with no difference in adverse effects rates for the secondary prevention of MACE. Although the polypill strategy was initially introduced to improve adherence to guideline-directed medical therapy (GDMT) for cardiovascular complications, the strategy has surpassed standard medical treatment for secondary prevention of MACE outcomes. Studies also showed improved medication compliance in underserved populations.

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来源期刊
Current Cardiology Reports
Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
6.20
自引率
2.70%
发文量
209
期刊介绍: The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.
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