糖基化牛奶低聚糖的潜在生物功能和未来展望。

IF 6.9 3区医学 Q1 CHEMISTRY, MEDICINAL

Archives of Pharmacal Research Pub Date : 2024-04-01 DOI:10.1007/s12272-024-01492-3

Thuy Le Lam Nguyen, Dung Van Nguyen, Kyung-Sun Heo

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引用次数: 0

摘要

ialyllactoses (SLs) 主要包括ialylated人乳低聚糖（HMOs）和牛乳低聚糖（BMOs）。首先，3'-sialyllactose（3'-SL）和 6'-sialyllactose（6'-SL）的安全性评估显示，它们在各种动物模型和人体参与者中的毒性较低。SL构成了一种独特的牛奶成分，突出了对婴儿发育至关重要的必需营养成分和生物活性成分，以及对各种疾病的众多相关健康益处。本综述探讨了 SLs 的安全性、生物合成和潜在生物效应，特别关注其对各种生理系统的影响，包括胃肠道系统、免疫系统疾病、罕见遗传疾病（如 GNE 肌病）、癌症、神经系统疾病、心血管疾病、各种癌症和病毒感染，从而说明其治疗潜力。

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Potential biological functions and future perspectives of sialylated milk oligosaccharides

Sialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety assessment of 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL) revealed low toxicity in various animal models and human participants. SLs constitute a unique milk component, highlighting the essential nutrients and bioactive components crucial for infant development, along with numerous associated health benefits for various diseases. This review explores the safety, biosynthesis, and potential biological effects of SLs, with a specific focus on their influence across various physiological systems, including the gastrointestinal system, immune disorders, rare genetic disorders (such as GNE myopathy), cancers, neurological disorders, cardiovascular diseases, diverse cancers, and viral infections, thus indicating their therapeutic potential.

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来源期刊

Archives of Pharmacal Research 医学-药学

CiteScore

13.40

自引率

9.00%

发文量

审稿时长

3.3 months

期刊介绍： Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.