女性 X 染色体功能剂量与昼夜节律调节之间的相互作用

IF 3.2 3区医学 Q2 PSYCHIATRY

Archives of Women's Mental Health Pub Date : 2024-04-02 DOI:10.1007/s00737-024-01452-2

Mariana Moysés-Oliveira, Monica L. Andersen, Sergio Tufik

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引用次数: 0

摘要

目的：人们对导致女性失眠症发病率较高的生物学因素和机制知之甚少。本研究的重点是 X 染色体功能失衡对两性神经系统的影响：受益于公开的大规模遗传、转录和表观基因组数据，我们整理并对比了不同的基因列表：（1）X 喜欢的基因，包括 X 染色体失活模式和疾病相关的分配；（2）睡眠相关基因；（3）丘脑上核的基因表达标记：结果：我们发现，在罕见遗传综合征和脑电波调节的背景下，X-连锁上核标记显著富集了临床相关基因：结论：在针对发病率存在性别偏差的精神和睡眠疾病设计医疗策略时，考虑大脑转录程序的女性特异性模式至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The interplay between X-chromosome functional dosage and circadian regulation in females

查看原文本刊更多论文

The interplay between X-chromosome functional dosage and circadian regulation in females

Purpose

Biological factors and mechanisms that drive higher prevalence of insomnia in females are poorly understood. This study focused on the neurological consequences of X-chromosome functional imbalances between sexes.

Methods

Benefited from publicly available large-scale genetic, transcriptional and epigenomic data, we curated and contrasted different gene lists: (1) X-liked genes, including assignments for X-chromosome inactivation patterns and disease associations; (2) sleep-associated genes; (3) gene expression markers for the suprachiasmatic nucleus.

Results

We show that X-linked markers for the suprachiasmatic nucleus are significantly enriched for clinically relevant genes in the context of rare genetic syndromes and brain waves modulation.

Conclusion

Considering female-specific patterns on brain transcriptional programs becomes essential when designing health care strategies for mental and sleep illnesses with sex bias in prevalence.

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来源期刊

Archives of Women's Mental Health 医学-精神病学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Women’s Mental Health is the official journal of the International Association for Women''s Mental Health, Marcé Society and the North American Society for Psychosocial Obstetrics and Gynecology (NASPOG). The exchange of knowledge between psychiatrists and obstetrician-gynecologists is one of the major aims of the journal. Its international scope includes psychodynamics, social and biological aspects of all psychiatric and psychosomatic disorders in women. The editors especially welcome interdisciplinary studies, focussing on the interface between psychiatry, psychosomatics, obstetrics and gynecology. Archives of Women’s Mental Health publishes rigorously reviewed research papers, short communications, case reports, review articles, invited editorials, historical perspectives, book reviews, letters to the editor, as well as conference abstracts. Only contributions written in English will be accepted. The journal assists clinicians, teachers and researchers to incorporate knowledge of all aspects of women’s mental health into current and future clinical care and research.