不同实验装置中细胞-细胞脱离力的定量比较。

IF 1.8 4区物理与天体物理 Q4 CHEMISTRY, PHYSICAL

The European Physical Journal E Pub Date : 2024-04-02 DOI:10.1140/epje/s10189-024-00416-9

Amit Singh Vishen, Jacques Prost, Pierre Sens

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引用次数: 0

摘要

我们比较了测量细胞-细胞粘附力的三种不同设置。我们发现，测量到的强度取决于所使用的设置类型。对于相同的细胞，不同的检测方法测得的脱离力不同。这可以从细胞-细胞分离是系统的整体特性这一事实中得到理解。我们还分析了外力和线张力对接触角和细胞脱离的作用。与实验的比较表明，粘性力在这一过程中发挥了重要作用。我们将这篇文章献给费尔-平卡斯，对我们许多人来说，他不仅是杰出科学的典范，也是人类行为的楷模。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Quantitative comparison of cell–cell detachment force in different experimental setups

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Quantitative comparison of cell–cell detachment force in different experimental setups

We compare three different setups for measuring cell–cell adhesion. We show that the measured strength depends on the type of setup that is used. For identical cells different assays measure different detachment forces. This can be understood from the fact that cell–cell detachment is a global property of the system. We also analyse the role of external force and line tension on contact angle and cell–cell detachment. Comparison with the experiments suggest that viscous forces play an important role in the process. We dedicate this article to Fyl Pincus who for many of us is an example to be followed not only for outstanding science but also for a marvelous human behavior.

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来源期刊

The European Physical Journal E CHEMISTRY, PHYSICAL-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

2.60

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： EPJ E publishes papers describing advances in the understanding of physical aspects of Soft, Liquid and Living Systems. Soft matter is a generic term for a large group of condensed, often heterogeneous systems -- often also called complex fluids -- that display a large response to weak external perturbations and that possess properties governed by slow internal dynamics. Flowing matter refers to all systems that can actually flow, from simple to multiphase liquids, from foams to granular matter. Living matter concerns the new physics that emerges from novel insights into the properties and behaviours of living systems. Furthermore, it aims at developing new concepts and quantitative approaches for the study of biological phenomena. Approaches from soft matter physics and statistical physics play a key role in this research. The journal includes reports of experimental, computational and theoretical studies and appeals to the broad interdisciplinary communities including physics, chemistry, biology, mathematics and materials science.