甘草酸及相关制剂:治疗肝病的灵感资源。

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-04-01 DOI:10.1142/S0192415X24500149
Yu Mou, Wenhao Liao, Yuchen Li, Lina Wan, Jingwen Liu, Xialing Luo, Hongping Shen, Qin Sun, Jing Wang, Jianyuan Tang, Zhilei Wang
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引用次数: 0

摘要

肝脏疾病及其相关并发症危害着全球数百万人的健康。无论是在中国还是在全球,肝病的预防和治疗仍然面临严峻挑战。随着生活水平的提高,包括非酒精性脂肪肝和酒精性肝病在内的代谢性肝病发病率以惊人的速度增长,导致更多的终末期肝病病例。因此,迫切需要发现治疗肝病的新型治疗药物。甘草苷(Glycyrrhizin,GL)是从甘草根中提取的一种三萜糖苷,具有广泛的药理和生物活性。目前,甘草酸苷制剂(GLPs)在治疗肝脏疾病方面具有一定的优势,临床效果好,不良反应少,通过多靶点治疗机制,包括抗脂肪肝、抗氧化应激、抗炎、免疫调节、抗纤维化、抗癌、药物相互作用等活性,显示出广阔的应用前景。本综述总结了目前已知的 GLPs 生物活性及其在肝病治疗中的医学应用,并强调了这些制剂作为有前途的治疗选择的潜力及其治疗肝病的诱人前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glycyrrhizin and the Related Preparations: An Inspiring Resource for the Treatment of Liver Diseases.

Liver diseases and their related complications endanger the health of millions of people worldwide. The prevention and treatment of liver diseases are still serious challenges both in China and globally. With the improvement of living standards, the prevalence of metabolic liver diseases, including non-alcoholic fatty liver disease and alcoholic liver disease, has increased at an alarming rate, resulting in more cases of end-stage liver disease. Therefore, the discovery of novel therapeutic drugs for the treatment of liver diseases is urgently needed. Glycyrrhizin (GL), a triterpene glycoside from the roots of licorice plants, possesses a wide range of pharmacological and biological activities. Currently, GL preparations (GLPs) have certain advantages in the treatment of liver diseases, with good clinical effects and fewer adverse reactions, and have shown broad application prospects through multitargeting therapeutic mechanisms, including antisteatotic, anti-oxidative stress, anti-inflammatory, immunoregulatory, antifibrotic, anticancer, and drug interaction activities. This review summarizes the currently known biological activities of GLPs and their medical applications in the treatment of liver diseases, and highlights the potential of these preparations as promising therapeutic options and their alluring prospects for the treatment of liver diseases.

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