塞马鲁肽的抗炎功效：技术现状

IF 4.2 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Clinical and Translational Endocrinology Pub Date : 2024-03-28 DOI:10.1016/j.jcte.2024.100340

Habib Yaribeygi , Mina Maleki , Tannaz Jamialahmadi , Amirhossein Sahebkar

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引用次数: 0

摘要

糖尿病患者往往存在慢性炎症和高水平的炎症细胞因子，从而导致胰岛素抵抗和并发症。有人建议使用抗炎药物来预防这些问题，包括使用具有抗炎特性的抗糖尿病药物，如 GLP-1 类似物塞马鲁肽。塞马鲁肽不仅能降低血糖，还具有潜在的抗炎作用。研究表明，它可以调节炎症反应，使糖尿病患者受益。然而，其抗炎作用的确切机制尚不完全清楚。本综述旨在讨论有关塞马鲁肽抗炎作用的最新发现以及其中的潜在途径。

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Anti-inflammatory benefits of semaglutide: State of the art

Individuals with diabetes often have chronic inflammation and high levels of inflammatory cytokines, leading to insulin resistance and complications. Anti-inflammatory agents are proposed to prevent these issues, including using antidiabetic medications with anti-inflammatory properties like semaglutide, a GLP-1 analogue. Semaglutide not only lowers glucose but also shows potential anti-inflammatory effects. Studies suggest it can modulate inflammatory responses and benefit those with diabetes. However, the exact mechanisms of its anti-inflammatory effects are not fully understood. This review aims to discuss the latest findings on semaglutide's anti-inflammatory effects and the potential pathways involved.

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来源期刊

Journal of Clinical and Translational Endocrinology ENDOCRINOLOGY & METABOLISM-

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

16 weeks