通过 EBUS-FNA 诊断 NUT 癌的诊断意义和细胞学特征，病例报告和文献综述。

IF 1.2 4区医学 Q4 CELL BIOLOGY

Cytopathology Pub Date : 2024-03-29 DOI:10.1111/cyt.13379

Yaping Ju, Miriam Velazquez, Andy Sherrod, Tiannan Wang

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引用次数: 0

摘要

NUT 癌的细胞形态学特征包括原始、单调、圆形至椭圆形肿瘤细胞的片状或离散巢状，N/C 比值高，有丝分裂活跃。鳞状细胞突然分化可能是诊断提示。NUT免疫组化染色阳性率超过50%即可诊断。NUT 癌是一种分化较差的恶性肿瘤，临床表现极具侵袭性，预后较差。它经常发生在中线器官，尤其是纵隔和肺部。EBUS-FNA 诊断胸腔和肺部病变的诊断率高，因此越来越多的人倾向于使用 EBUS-FNA 手术。因此，识别 NUT 癌的细胞形态学特征对于及时治疗和提高患者生存率至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Diagnostic significance and cytological features of NUT carcinoma by EBUS-FNA, a case report and literature review

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Diagnostic significance and cytological features of NUT carcinoma by EBUS-FNA, a case report and literature review

Cytomorphological features of NUT carcinoma include sheets or discrete nests of primitive, monotonous, round to oval shaped tumour cells with high N/C ratio and brisk mitotic figures. Abrupt squamous differentiation might be a diagnostic hint. More than 50% positivity of NUT immunohistochemistry staining is diagnostic.

NUT carcinoma represents a poorly differentiated malignancy by extremely aggressive clinical course and poor prognosis. It frequently manifests in midline organs, notably in the mediastinum and lung. The rising preferences for utilizing the EBUS-FNA procedure in diagnosing thoracic and lung lesions stems from its high diagnostic yield. Hence, recognizing the cytomorphological features of NUT carcinoma is crucial for timely treatment and improved patient survival.

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来源期刊

Cytopathology 生物-病理学

CiteScore

2.30

自引率

15.40%

发文量

107

审稿时长

6-12 weeks

期刊介绍： The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy. Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.