Lucimara Rodrigues Carobeli, Ana Beatriz Camillo Santos, Laura Beatriz Marques Martins, Edilson Damke, Marcia Edilaine Lopes Consolaro
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We selected original articles focusing on 'Uterine Cervical Neoplasms' and 'Photochemotherapy and Chemotherapy' published in the last 10 years. The risk of bias in the studies was assessed using the CONSORT and SYRCLE tools.</p><p><strong>Results: </strong>Twenty-three original articles were included, focusing on HeLa cells, derived from endocervical adenocarcinoma and on combinations of several chemotherapeutics. 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引用次数: 0
摘要
导言:尽管有证据表明,光动力疗法(PDT)与化疗相结合具有克服单一疗法局限性的巨大潜力,但人们对这种联合疗法治疗宫颈癌的现状知之甚少。本系统综述旨在探讨目前在不同研究模型和宫颈癌临床试验中将光动力疗法与化疗相结合的进展情况:我们根据 PRISMA 声明和开放科学框架审查协议,使用 PubMed、Web of Science、Embase、Scopus、LILACS 和 Cochrane 数据库进行了系统审查。我们选择了过去十年间发表的以 "子宫颈肿瘤 "和 "光化学疗法和化疗 "为主题的原创文章。结果:共收录了 23 篇原创文章,这些文章的研究重点是宫颈内膜腺癌的 HeLa 细胞以及几种化疗药物的组合。与单一疗法相比,这些组合疗法的细胞毒性有所提高:尽管缺乏动物实验和临床研究,但化疗与光动力疗法的结合是宫颈癌治疗的一种潜在选择,需要进一步研究。Osf 注册:https://doi.org/10.17605/OSF.IO/WPHN5。
Recent advances in photodynamic therapy combined with chemotherapy for cervical cancer: a systematic review.
Introduction: Despite the evidence that photodynamic therapy (PDT) associated with chemotherapy presents great potential to overcome the limitations of monotherapy, little is known about the current status of this combination against cervical cancer. This systematic review aimed to address the currently available advances in combining PDT and chemotherapy in different research models and clinical trials of cervical cancer.
Methods: We conducted a systematic review based on PRISMA Statement and Open Science Framework review protocol using PubMed, Web of Science, Embase, Scopus, LILACS, and Cochrane databases. We selected original articles focusing on 'Uterine Cervical Neoplasms' and 'Photochemotherapy and Chemotherapy' published in the last 10 years. The risk of bias in the studies was assessed using the CONSORT and SYRCLE tools.
Results: Twenty-three original articles were included, focusing on HeLa cells, derived from endocervical adenocarcinoma and on combinations of several chemotherapeutics. Most of the combinations used modern drug delivery systems for improved simultaneous delivery and presented promising results with increased cytotoxicity compared to monotherapy.
Conclusion: Despite the scarcity of animal studies and the absence of clinical studies, the combination of chemotherapy with PDT presents a potential option for cervical cancer therapy requiring additional studies.
Osf registration: https://doi.org/10.17605/OSF.IO/WPHN5 [Figure: see text].
期刊介绍:
Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches.
Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care.
Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections:
Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results
Article Highlights – an executive summary of the author’s most critical points.