一例由慢性中耳炎黄曲霉菌引起的颅内感染病例

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports Pub Date : 2024-02-28 DOI:10.1016/j.mmcr.2024.100637

Ling Yang , Jiacun Su , Chao Zhuo

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引用次数: 0

摘要

中枢神经系统（CNS）曲霉菌病在免疫功能正常的患者中并不常见。我们接诊了一名患有慢性中耳炎和糖尿病的 64 岁男性患者。通过元基因组学新一代测序技术在脑脊液中发现了黄曲霉菌。最初的伏立康唑治疗缓解有限，但根据药物浓度进行个性化剂量调整后，病情得到缓解。该病例强调了针对中枢神经系统曲霉菌感染采用多样化诊断方法和定制疗法的重要性。

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A case of intracranial infection caused by Aspergillus flavus originating from chronic otitis media

Central nervous system (CNS) aspergillosis is uncommon in immunocompetent patients. We present a 64-year-old man with chronic otitis media and uncontrolled diabetes. Aspergillus flavus was identified in cerebrospinal fluid via metagenomics next-generation sequencing technology. Initial voriconazole treatment offered limited relief, but personalized dosage adjustments, guided by drug concentration, led to remission. This case underscores the importance of diverse diagnostic approaches and tailored therapy for CNS Aspergillus infections.

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来源期刊

Medical Mycology Case Reports MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

47 days