18F-FDG PET/CT 代谢多参数预测局部进展期胃癌的化疗疗效。

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Luqiang Jin, Linghe Zhang, Liping Fu, Fahuan Song, Aiping Cheng
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引用次数: 0

摘要

目的:本研究旨在利用18F-FDG PET/CT多参数定量分析确定局部进展期胃癌患者新辅助化疗的疗效:我们对34例接受新辅助化疗和手术的病理鉴定胃癌患者进行了回顾性分析。对化疗方案进行了跟踪,并进行了 18F-FDG PET/CT 分析。我们确定了治疗前后靶病变的多参数,并确定了生物标志物百分比变化的理想临界值。使用二元逻辑回归对独立因素进行了评估。采用反应分类系统探讨代谢和解剖反应与病理缓解程度之间的关联:二元逻辑回归分析表明,劳伦肠类型和总病灶糖酵解变化>45.2%是新辅助化疗疗效的风险预测因素;总病灶糖酵解显示出最佳预测疗效。与单模块反应(代谢或解剖反应)组相比,双模块反应(代谢和解剖反应)组的分类变量系统具有更高的预测准确性:通过18F-FDG PET/CT多参数定量分析,劳伦肠类型和总病变糖酵解变化>45.2%是胃腺癌患者新辅助化疗疗效的独立预测指标。此外,双模块评估也显示出较高的预测效力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
18F-FDG PET/CT metabolism multi-parameter prediction of chemotherapy efficacy in locally progressive gastric cancer

Purpose

This study aimed to use an 18F-FDG PET/CT multiparametric quantitative analysis to determine the efficacy of neoadjuvant chemotherapy in patients with locally progressive gastric cancer.

Materials and methods

We conducted a retrospective analysis of 34 patients with pathologically identified gastric cancer who received neoadjuvant chemotherapy and surgery. Chemotherapy regimens were followed and 18F-FDG PET/CT was conducted. We ascertained multiparamaters of the target lesions pre- and post-treatment and determined the ideal cutoff values for the percentage change in biomarkers. Independent factors were evaluated using binary logistic regression. A response classification system was used to explore the association between metabolic and anatomical responses and the degree of pathological remission.

Results

Binary logistic regression analysis showed that Lauren bowel type and change in total lesion glycolysis >45.2% were risk predictors for the efficacy of neoadjuvant chemotherapy; total lesion glycolysis demonstrated the best predictive efficacy. The categorical variable system of the two-module response (metabolic and anatomical response) group had a higher predictive accuracy than that of the single-module response (metabolic or anatomical response) group.

Conclusions

Using 18F-FDG PET/CT multiparametric quantitative analysis, Lauren bowel type and change in total lesion glycolysis >45.2% were independent predictors of the efficacy of neoadjuvant chemotherapy in patients with gastric adenocarcinoma. Additionally, the dual-module assessment demonstrated high predictive efficacy.

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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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