{"title":"聚丙烯酸:用于可控给药的生物相容性和可生物降解聚合物","authors":"Hossein Eslami, Mojtaba Ansari, Ahmad Darvishi, Hossein Rayat Pisheh, Mahdieh Shami, Faezeh Kazemi","doi":"10.1134/S0965545X2460011X","DOIUrl":null,"url":null,"abstract":"<p>Polyacrylic acid is a biocompatible and biodegradable polymer that has been widely investigated for use in drug delivery. It has a number of properties that make polyacrylic acid a promising material for various applications, including ability to form hydrogels, mucoadhesive properties, and stimuli-responsive behavior. Polyacrylic acid hydrogels can be used to deliver drugs to a variety of tissues and organs. They can be prepared in a variety of forms, including injectable gels, films, and tablets. These hydrogels can be loaded with a variety of drugs, including proteins, peptides, and small molecules. The mucoadhesive properties of polyacrylic acid make it a good choice for delivering drugs to the eye, nose, and skin. Polyacrylic acid can adhere to these mucosal surfaces, which can help to prolong the drug’s release and improve its bioavailability. The stimuli-responsive behavior of polyacrylic acid can be used to develop drug delivery systems that release drugs in response to specific stimuli, such as changes in pH, temperature, or ionic strength. This can be used to control the release of drugs in a way that is tailored to the specific needs of the patient. The research on the use of polyacrylic acid in drug delivery is ongoing. As our understanding of its properties and behavior improves, we can expect to see even more innovative and effective drug delivery systems developed in the future.</p>","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"65 6","pages":"702 - 713"},"PeriodicalIF":1.0000,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Polyacrylic Acid: A Biocompatible and Biodegradable Polymer for Controlled Drug Delivery\",\"authors\":\"Hossein Eslami, Mojtaba Ansari, Ahmad Darvishi, Hossein Rayat Pisheh, Mahdieh Shami, Faezeh Kazemi\",\"doi\":\"10.1134/S0965545X2460011X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Polyacrylic acid is a biocompatible and biodegradable polymer that has been widely investigated for use in drug delivery. It has a number of properties that make polyacrylic acid a promising material for various applications, including ability to form hydrogels, mucoadhesive properties, and stimuli-responsive behavior. Polyacrylic acid hydrogels can be used to deliver drugs to a variety of tissues and organs. They can be prepared in a variety of forms, including injectable gels, films, and tablets. These hydrogels can be loaded with a variety of drugs, including proteins, peptides, and small molecules. The mucoadhesive properties of polyacrylic acid make it a good choice for delivering drugs to the eye, nose, and skin. Polyacrylic acid can adhere to these mucosal surfaces, which can help to prolong the drug’s release and improve its bioavailability. The stimuli-responsive behavior of polyacrylic acid can be used to develop drug delivery systems that release drugs in response to specific stimuli, such as changes in pH, temperature, or ionic strength. This can be used to control the release of drugs in a way that is tailored to the specific needs of the patient. The research on the use of polyacrylic acid in drug delivery is ongoing. As our understanding of its properties and behavior improves, we can expect to see even more innovative and effective drug delivery systems developed in the future.</p>\",\"PeriodicalId\":738,\"journal\":{\"name\":\"Polymer Science, Series A\",\"volume\":\"65 6\",\"pages\":\"702 - 713\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polymer Science, Series A\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S0965545X2460011X\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Science, Series A","FirstCategoryId":"1","ListUrlMain":"https://link.springer.com/article/10.1134/S0965545X2460011X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Polyacrylic Acid: A Biocompatible and Biodegradable Polymer for Controlled Drug Delivery
Polyacrylic acid is a biocompatible and biodegradable polymer that has been widely investigated for use in drug delivery. It has a number of properties that make polyacrylic acid a promising material for various applications, including ability to form hydrogels, mucoadhesive properties, and stimuli-responsive behavior. Polyacrylic acid hydrogels can be used to deliver drugs to a variety of tissues and organs. They can be prepared in a variety of forms, including injectable gels, films, and tablets. These hydrogels can be loaded with a variety of drugs, including proteins, peptides, and small molecules. The mucoadhesive properties of polyacrylic acid make it a good choice for delivering drugs to the eye, nose, and skin. Polyacrylic acid can adhere to these mucosal surfaces, which can help to prolong the drug’s release and improve its bioavailability. The stimuli-responsive behavior of polyacrylic acid can be used to develop drug delivery systems that release drugs in response to specific stimuli, such as changes in pH, temperature, or ionic strength. This can be used to control the release of drugs in a way that is tailored to the specific needs of the patient. The research on the use of polyacrylic acid in drug delivery is ongoing. As our understanding of its properties and behavior improves, we can expect to see even more innovative and effective drug delivery systems developed in the future.
期刊介绍:
Polymer Science, Series A is a journal published in collaboration with the Russian Academy of Sciences. Series A includes experimental and theoretical papers and reviews devoted to physicochemical studies of the structure and properties of polymers (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed. Online submission via Internet to the Series A, B, and C is available at http://polymsci.ru.