聚丙烯酸:用于可控给药的生物相容性和可生物降解聚合物

IF 1 4区 化学 Q4 POLYMER SCIENCE
Hossein Eslami, Mojtaba Ansari, Ahmad Darvishi, Hossein Rayat Pisheh, Mahdieh Shami, Faezeh Kazemi
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引用次数: 0

摘要

摘要 聚丙烯酸是一种生物相容性和可生物降解的聚合物,已被广泛研究用于给药。聚丙烯酸具有多种特性,包括形成水凝胶的能力、粘液粘附性和刺激响应行为,因此是一种具有多种应用前景的材料。聚丙烯酸水凝胶可用于向各种组织和器官输送药物。它们的制备形式多种多样,包括可注射凝胶、薄膜和片剂。这些水凝胶可以装载各种药物,包括蛋白质、肽和小分子。聚丙烯酸的粘液粘附特性使其成为向眼、鼻和皮肤输送药物的理想选择。聚丙烯酸可粘附在这些粘膜表面,有助于延长药物的释放时间,提高生物利用率。聚丙烯酸的刺激响应特性可用于开发药物释放系统,该系统可根据特定刺激(如 pH 值、温度或离子强度的变化)释放药物。这可用于控制药物的释放,以满足患者的特定需求。有关聚丙烯酸在给药中的应用的研究仍在继续。随着我们对聚丙烯酸特性和行为的了解不断加深,我们有望在未来看到更多创新、有效的给药系统被开发出来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Polyacrylic Acid: A Biocompatible and Biodegradable Polymer for Controlled Drug Delivery

Polyacrylic Acid: A Biocompatible and Biodegradable Polymer for Controlled Drug Delivery

Polyacrylic Acid: A Biocompatible and Biodegradable Polymer for Controlled Drug Delivery

Polyacrylic acid is a biocompatible and biodegradable polymer that has been widely investigated for use in drug delivery. It has a number of properties that make polyacrylic acid a promising material for various applications, including ability to form hydrogels, mucoadhesive properties, and stimuli-responsive behavior. Polyacrylic acid hydrogels can be used to deliver drugs to a variety of tissues and organs. They can be prepared in a variety of forms, including injectable gels, films, and tablets. These hydrogels can be loaded with a variety of drugs, including proteins, peptides, and small molecules. The mucoadhesive properties of polyacrylic acid make it a good choice for delivering drugs to the eye, nose, and skin. Polyacrylic acid can adhere to these mucosal surfaces, which can help to prolong the drug’s release and improve its bioavailability. The stimuli-responsive behavior of polyacrylic acid can be used to develop drug delivery systems that release drugs in response to specific stimuli, such as changes in pH, temperature, or ionic strength. This can be used to control the release of drugs in a way that is tailored to the specific needs of the patient. The research on the use of polyacrylic acid in drug delivery is ongoing. As our understanding of its properties and behavior improves, we can expect to see even more innovative and effective drug delivery systems developed in the future.

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来源期刊
Polymer Science, Series A
Polymer Science, Series A 化学-高分子科学
CiteScore
1.70
自引率
0.00%
发文量
55
审稿时长
3 months
期刊介绍: Polymer Science, Series A is a journal published in collaboration with the Russian Academy of Sciences. Series A includes experimental and theoretical papers and reviews devoted to physicochemical studies of the structure and properties of polymers (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed. Online submission via Internet to the Series A, B, and C is available at http://polymsci.ru.
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