治疗小儿血液恶性肿瘤继发的膝关节骨坏死的骨科治疗现状综述。

IF 1.4 Q3 ORTHOPEDICS

Orthopedic Reviews Pub Date : 2024-03-24 eCollection Date: 2024-01-01 DOI:10.52965/001c.115354

Caleb P Gottlich, John C Fisher, Michel Diab

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引用次数: 0

摘要

急性淋巴细胞白血病是最常见的儿童血液系统恶性肿瘤。对这种疾病的治疗已经取得了重大进展，现在的治愈率高达 90%。虽然这些患者通常都能摆脱疾病，但治疗可能会在疾病负担减轻后留下长期的破坏性影响。常见的治疗后果是骨坏死（ON），通常发生在负重关节。这部分患者的最佳治疗方法尚不确定。在这篇综述中，我们将介绍骨坏死的病因、疑似发病机制以及文献中描述的治疗方案。

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A Current Review in the Orthopedic Management of Osteonecrosis of the knee Secondary to Treatment of Pediatric Hematologic Malignancy.

Acute Lymphoblastic Leukemia is the most prevalent pediatric hematologic malignancy. The treatment for this illness has advanced significantly, now touting a 90% cure rate. Although these patients often become disease free, treatment can leave devastating effects that last long after their disease burden is alleviated. A commonly experienced result of treatment is osteonecrosis (ON), often occurring in weight bearing joints. Uncertainty exists in the optimal treatment of this cohort of patients. In this review, we describe the etiology and suspected pathogenesis of ON, as well as treatment options described in the literature.

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来源期刊

Orthopedic Reviews ORTHOPEDICS-

CiteScore

2.70

自引率

4.80%

发文量

122

审稿时长

10 weeks

期刊介绍： Orthopedic Reviews is an Open Access, online-only, peer-reviewed journal that considers articles concerned with any aspect of orthopedics, as well as diagnosis and treatment, trauma, surgical procedures, arthroscopy, sports medicine, rehabilitation, pediatric and geriatric orthopedics. All bone-related molecular and cell biology, genetics, pathophysiology and epidemiology papers are also welcome. The journal publishes original articles, brief reports, reviews and case reports of general interest.