蝾螈有助于研究临床应用中的非典型器官再生机制

Medicine Advances Pub Date : 2024-03-05 DOI:10.1002/med4.49
Binxu Yin, Xiao Cui, Yanmei Liu, Ji-Feng Fei
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引用次数: 0

摘要

在四足脊椎动物中,蝾螈具有非凡的器官再生能力。以往的研究主要集中在研究四肢、尾部、大脑、脊髓、心脏和晶状体等典型组织或器官的再生。这些领域取得的进展不仅对蝾螈,而且对其他脊椎动物了解这些器官的再生和开发治疗方法具有广泛的意义。近年来,人们对研究蝾螈非典型器官(如肝脏、肺脏、肾脏和胰腺)的再生越来越感兴趣。这种多样化的研究开辟了新的途径,并为具有挑战性的临床问题提供了潜在的解决方案。本综述旨在总结蝾螈非典型器官再生领域所取得的进展,并展望未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Salamanders aid research into mechanisms of non-canonical organ regeneration for clinical applications

Salamanders aid research into mechanisms of non-canonical organ regeneration for clinical applications

Salamanders possess remarkable regenerative capacities for organ regeneration among tetrapod vertebrates. Previous research has primarily focused on studying the regeneration of canonical tissues or organs such as limbs, tail, brain, spinal cord, heart, and lens. The advancements made in these areas have broader implications for understanding regeneration and developing therapeutic approaches for these organs, not only in salamanders but also in other vertebrates. In recent years, there has been an increasing interest in studying the regeneration of non-canonical organs in salamanders, such as the liver, lungs, kidneys, and pancreas. This diversification of research has opened up new avenues and provided potential solutions to challenging clinical problems. This review aims to summarize the progress made in the field of non-canonical organ regeneration in salamanders and provides an outlook on future research directions.

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