DIAGNOSTIC ACCURACY OF DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MYOMETRIAL INVASION AMONG PATIENTS WITH ENDOMETRIAL CARCINOMA

OBJECTIVE: To determine the accuracy of magnetic resonance diffusion-weighted imaging in the diagnosis of myometrial invasion in patients with carcinoma endometrium keeping histopathology as the gold standard. MATERIALS AND METHODS:  It was a descriptive cross-sectional study carried out from 11 July 2019 to 10 July 2021 at the Radiology Department, Khyber Teaching Hospital, Peshawar. The sample was collected via a Non-probability sampling technique. The sample size was 141 taking the prevalence of myometrial invasion 46% 12 with sensitivity and specificity of DW-MRI 90% and 73%,95% confidence level, and 10% margin of error. All women presenting with biopsy-proven endometrial carcinoma scheduled for hysterectomy, aged between 30 to 70 years were included. The myometrial invasion via MRI pelvis including DWI, with a 1.5 T machine (Philips), was evaluated for all patients. After a hysterectomy, myometrial invasion was confirmed on histopathology. RESULTS: Among 141 women, 58 (41%) patients were between 30-50 years of age, and 83(59%) patients were in the 51-70 years age group. DW-MRI had 91.11% sensitivity, 66.66% specificity, 98.4% Positive predictive value, 25% Negative predictive value, and 90.07% diagnostic accuracy CONCLUSION: In carcinoma endometrium, MR-DWI has good diagnostic accuracy in the detection of myometrial invasion. Keywords: Endometrial cancer, Diffusion-weighted magnetic resonance imaging, Histopathology.