氰乙酰苯胺衍生物的多组分反应：香豆素和喹啉衍生物的合成及其细胞毒性评估

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-12 DOI:10.4314/bcse.v38i3.15

R. M. Mohareb, Magdy K. Zahran, Hager R. Maghraby, Amira E.M. Abdallah

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引用次数: 0

摘要

本研究合成了几个涉及四氢苯并吡喃 7a-i 和四氢苯并吡啶 9a-i 的融合杂环系统。这些反应通过不同芳香醛、氰乙酰苯胺衍生物和环己烷-1,3-二酮的多组分反应进行。以 A549、HT-29、MKN-45、U87MG、SMMC-7721 和 H460 等六种癌细胞系为阳性对照，利用 foretinib 和标准 MTT 法进行体外抗癌活性测试。结果表明，合成的许多衍生物对所用的所有癌细胞株都最有效，其中 6 种化合物 7e、7f、9b、9d、9e 和 9g 的效力最高。本研究获得的结果有助于今后的进一步研究。关键词：多组分反应氰乙酰苯胺吡喃吡啶细胞毒性 Bull.Chem.Soc.2024, 38(3), 739-750. DOI: https://dx.doi.org/10.4314/bcse.v38i3.15

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Multicomponent reactions of cyanoacetanilide derivatives: Synthesis of coumarin and quinoline derivative and evaluations of their cytotoxicity

In this study, several fused heterocyclic systems involving tetrahydrobenzopyrans 7a-i and tetrahydrobenzopyridines 9a-i were synthesized. The reactions proceed via a multicomponent reaction of different aromatic aldehydes, cyanoacetanilide derivatives, and cyclohexane-1,3-dione. All the produced compounds were tested for their anticancer activity by using six cancer cell lines such as A549, HT-29, MKN-45, U87MG, SMMC-7721 and H460 utilizing foretinib as the positive control and the standard MTT assay in vitro. The results indicated that many synthesized derivatives were the most potent towards all the cancer cell lines used, six compounds 7e, 7f, 9b, 9d, 9e, and 9g showed the highest potency. The results obtained in this work enhance further investigations in the future. KEY WORDS: Multi-component reactions, Cyanoacetanilide, Pyran, Pyridine, Cytotoxicity Bull. Chem. Soc. Ethiop. 2024, 38(3), 739-750. DOI: https://dx.doi.org/10.4314/bcse.v38i3.15

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.