并发性房室传导阻滞 类风湿性关节炎 完全性和心内肿块

Bouamoud Asmaa
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摘要

类风湿性关节炎(RA)是一种慢性自身免疫性关节疾病,以持续性全身炎症为特征。在类风湿性关节炎中,心脏受累并不少见,可累及心脏的所有三个外膜。我们报告了一例伴有完全性房室传导阻滞(AVB)和心脏内移动性肿块的类风湿关节炎病例。这是一名最初服用氯喹的 RA 患者,并发完全性房室传导阻滞,植入了双腔起搏器,随后服用皮质类固醇和甲氨蝶呤长达四年。面对骨质疏松症的恶化和起搏器刺激阈值的升高,医生决定用来氟米特取代甲氨蝶呤。在对患者进行心脏评估时,进行了 ETT 检查,无意中发现右心房内有一个肿块,与心房管和三尖瓣相连,但没有阻塞。完全性 BAV 非常罕见。它尤其可见于老年多关节炎。有几种机制可以解释这种情况,包括类风湿结节、氯喹中毒、淀粉样蛋白浸润和类风湿血管炎。类风湿关节炎与心内肿块的关联非常罕见。通过分析文献中描述的少数病例,总结出五种主要病因:类风湿结节、癌症、瓣膜肉芽肿病、腔内血栓和感染性心内膜炎。我们通过自己的病例讨论了类风湿关节炎与主要传导性疾病相关的流行病学和病因学特殊性,以及在类风湿关节炎的背景下对心内肿块进行病因学诊断的难度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Complicated Atrioventricular Block Rheumatoid Arthritis Complete and Intracardiac Mass
Rheumatoid Arthritis (RA) is a chronic autoimmune joint disease characterized by persistent systemic inflammation. In rheumatoid arthritis, cardiac involvement is not uncommon and may involve all three tunics of the heart. We report an ex - ceptional case of RA associated with complete Atrioventricular Block (AVB) and intracardiac mobile mass. This is a patient with RA initially put on chloroquine, complicated by a complete BAV implanted with a double chamber pace, then put on corticosteroid therapy and methotrexate for four years. Faced with the worsening of his osteoporosis and the prob - able increase in the threshold of pacemaker stimulation, it was decided to replace methotrexate with leflunomide. As part of the patient's cardiac evaluation, an ETT was performed, inadvertently objectifying a mass in the right atrium attached to the atrial tube and the tricuspid valve without obstruction. Full BAV is very rare. It can be seen especially in old polyarthritis. Several mechanisms can explain this, including rheumatoid nodules; Chloroquine poisoning; amyloid infiltration and rheumatoid vasculitis. The association of RA and intracardiac mass is rare. By analyzing the few cases described in the literature, five main causes are summarized: rheumatoid nodules, cancers, granulomatosis of valves, intracavitary thrombus and infective endocarditis. We discuss through our case, the epidemiological and etiological particularity of the association of RA with a major conductive disorder, as well as the difficulty of the etiological diagnosis of an intracardiac mass in the context of RA.
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