参与骨修复的细胞及其潜在临床应用的最新进展

SurgiColl Pub Date : 2024-03-23 DOI:10.58616/001c.90443
E. C. Rodríguez-Merchán
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引用次数: 0

摘要

这篇文献综述总结了与骨愈合不同阶段有关的细胞及其潜在临床应用的最新进展,包括炎症阶段(中性粒细胞、巨噬细胞、肥大细胞)、纤维血管阶段(内皮细胞和间充质干细胞)、骨形成(成骨细胞、软骨细胞)和胼胝体重塑(破骨细胞)。一些研究证实了两个众所周知的事实,即酒精摄入和地塞米松会对骨愈合产生负面影响。其他研究表明,澳库宾、硼替佐米和人脐带间充质干细胞(HUCMSCs)Wnt10b可促进骨折的骨愈合。然而,还需要更多的研究来证实它们在骨折治疗临床实践中的实际效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent developments on cells involved in bone repair and their potential clinical applications
This review of the literature has summarized recent developments on cells implicated in the different phases of bone healing and their potential clinical applications including inflammatory phase (neutrophils, macrophages, mast cells), fibrovascular phase (endothelial cells and mesenchymal stem cells - MSCs), bone formation (osteoblasts, chondrocytes), and callus remodeling (osteoclasts). Some studies have confirmed the two well-known facts that alcohol intake and dexamethasone negatively affect bone healing. Other studies have shown that Aucubin, Bortezomib, and human umbilical cord MSCs (HUCMSCs)Wnt10b promote bone healing of bone fractures. However, more research is needed to confirm their actual utility in the clinical practice of bone fracture treatment.
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