O 链接β-N-乙酰葡糖胺化可能是促进骨髓间充质基质细胞成骨分化的关键调节因子

IF 3.6 3区医学 Q3 CELL & TISSUE ENGINEERING

World journal of stem cells Pub Date : 2024-03-26 DOI:10.4252/wjsc.v16.i3.228

Xu-Chang Zhou, Guo-Xin Ni

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引用次数: 0

摘要

累积的证据表明，O-连锁β-N-乙酰葡萄糖氨酰化（O-GlcNAcylation）在病理生理过程中发挥着重要的调控作用。虽然O-GlcNAcylation在肿瘤中的调控机制已逐渐被阐明，但O-GlcNAcylation在骨代谢中，尤其是在骨髓间充质基质细胞（BMSCs）成骨分化中的潜在机制仍有待探索。本研究对 O-GlcNAcylation 与骨髓间充质基质细胞成骨分化的相关文献进行了综述，希望能引起更多学者关注 O-GlcNAcylation 与骨代谢的相关研究，并为开发骨质疏松症等骨代谢疾病的新型治疗靶点提供启示。

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O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells

Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated, the potential mechanisms of O-GlcNAcylation in bone metabolism, particularly, in the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) remains unexplored. In this study, the literature related to O-GlcNAcylation and BMSC osteogenic differentiation was reviewed, assuming that it could trigger more scholars to focus on research related to O-GlcNAcylation and bone metabolism and provide insights into the development of novel therapeutic targets for bone metabolism disorders such as osteoporosis.

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来源期刊

World journal of stem cells Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

7.80

自引率

4.90%

发文量

750

期刊介绍： The World Journal of Stem Cells (WJSC) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of stem cells. It was launched on December 31, 2009 and is published monthly (12 issues annually) by BPG, the world''s leading professional clinical medical journal publishing company.