平衡神经元活动，对抗神经发育障碍。

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-03-22 DOI:10.1016/j.tins.2024.03.002

Stephanie Le, Carmen Menacho, Alessandro Prigione

引用次数: 0

摘要

在最近的一项研究中，Rylaarsdam 及其同事发现，导致一种罕见神经发育综合征的突变 PACS1 基因会影响人类神经元的发射能力，但不会导致脑器官组织的细胞结构失调。这些研究结果表明，神经元电生理学异常可能成为影响大脑发育的儿科疾病的干预目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Balancing neuronal activity to fight neurodevelopmental disorders.

In a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.