代谢健康的年轻烟草使用者的糖尿病前期与中风的关系:基于人群的分析

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Advait Vasavada , Arankesh Mahadevan , Manisha Jain , Subramanian Gnanaguruparan , Rupak Desai
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引用次数: 0

摘要

背景糖尿病和吸烟是中风的既定风险因素。然而,糖尿病前期、烟草使用和中风在年轻人中的交集仍未得到充分探讨。本研究旨在调查年轻烟草使用者中糖尿病前期与中风风险之间的关联。方法利用全国住院患者样本(2019 年)和相关 ICD-10 编码,我们确定了患有烟草使用障碍和糖尿病前期的年轻患者。回归分析考虑了风险因素(性别、人口统计学、收入、合并症)以评估中风几率。糖尿病前期患者通常年龄较大(中位年龄 36 岁对 31 岁)、男性(59.4%)、黑人(33.8%)和西班牙裔(12.2%),合并症发生率较高,包括药物滥用、酗酒、慢性阻塞性肺病和慢性肾脏病(p < 0.001)。他们发生中风事件的比例也更高(1.9% 对 0.5%,p <0.001)。在对混杂因素进行调整后进行多变量分析,患有糖尿病前期、代谢健康的年轻吸烟者发生中风的风险更高(aOR 3.31,95 % CI [1.67-6.55],p <0.001)。有必要开展前瞻性研究,探讨在吸烟情况下糖尿病前期与中风之间的因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association of prediabetes with stroke in young metabolically healthy tobacco users: A population-based analysis

Association of prediabetes with stroke in young metabolically healthy tobacco users: A population-based analysis

Background

Diabetes and tobacco use are well-established risk factors for stroke. However, the intersection of prediabetes, tobacco use, and stroke among young individuals remains underexplored. This study aims to investigate the association between pre-diabetes and stroke risk in young tobacco users.

Methods

Using the National Inpatient Sample (2019) and relevant ICD-10 codes, we identified young patients with tobacco use disorder and pre-diabetes. Regression analysis considered risk factors (gender, demographics, income, comorbidities) to assess stroke odds.

Results

Among 1,017,540 stroke hospitalizations, 1.9 % were pre-diabetic. Pre-diabetics were often older (median age 36 vs. 31), male (59.4 %), Black (33.8 %), and Hispanic (12.2 %), with higher rates of comorbidities, including drug abuse, alcohol abuse, COPD, and CKD (p < 0.001). They also exhibited higher rates of stroke events (1.9 % vs. 0.5 %, p < 0.001). Multivariable analysis after adjusting for confounders, young metabolically healthy smokers with pre-diabetes had a higher risk of stroke (aOR 3.31, 95 % CI [1.67–6.55], p < 0.001).

Conclusion

Prediabetes could potentially triple stroke risk in young tobacco smokers. Prospective research is warranted to explore the causal association between pre-diabetes and stroke in the setting of tobacco use.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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