TBK1 在癌症免疫生物学中的新作用。

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI:10.1016/j.trecan.2024.02.007

Alex Miranda, Carl A Shirley, Russell W Jenkins

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引用次数: 0

摘要

TANK 结合激酶 1（TBK1）是一种多功能丝氨酸/苏氨酸蛋白激酶，在先天性免疫、新陈代谢、自噬、细胞死亡和炎症中发挥着既定的作用。TBK1 因其在调节先天性免疫中的作用而闻名，但由于其在调节细胞对来自免疫系统的炎症信号的反应方面的作用，它已成为一种癌细胞内在免疫逃避基因。除了对癌细胞的影响，TBK1 似乎还能调节肿瘤免疫微环境中的淋巴细胞和骨髓细胞。在这篇综述中，我们将详细介绍最近在了解 TBK1 在肿瘤免疫中的内在和外在作用和调控方面取得的进展。

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Emerging roles of TBK1 in cancer immunobiology.

TANK-binding kinase 1 (TBK1) is a versatile serine/threonine protein kinase with established roles in innate immunity, metabolism, autophagy, cell death, and inflammation. While best known for its role in regulating innate immunity, TBK1 has emerged as a cancer cell-intrinsic immune evasion gene by virtue of its role in modulating cellular responses to inflammatory signals emanating from the immune system. Beyond its effect on cancer cells, TBK1 appears to regulate lymphoid and myeloid cells in the tumor immune microenvironment. In this review, we detail recent advances in our understanding of the tumor-intrinsic and -extrinsic roles and regulation of TBK1 in tumor immunity.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.