真菌天然产物生物生成过程中的非酶反应。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2024-03-22 DOI:10.1007/s11418-024-01797-z

Shinji Kishimoto

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引用次数: 0

摘要

长期以来，真菌一直被认为是具有重要生物活性的天然产物（NPs）的丰富来源。几十年来对真菌 NPs 生物合成的研究表明，大多数生物合成步骤是由生物合成基因簇中编码的复杂酶催化的，而有些反应则是在没有酶的情况下进行的。这些非酶反应使 NPs 的生物合成分析变得复杂，并对产品结构的多样化起着重要作用。因此，了解非酶反应对于阐明生物合成机制非常重要。本综述重点介绍我们最近在四种 NPs（病毒素、Sch210972、扁桃肽和扁桃呋喃碱）的生物合成研究中遇到的非酶反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Non-enzymatic reactions in biogenesis of fungal natural products

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Non-enzymatic reactions in biogenesis of fungal natural products

Fungi have long been regarded as abundant sources of natural products (NPs) exhibiting significant biological activities. Decades of studies on the biosynthesis of fungal NPs revealed that most of the biosynthetic steps are catalyzed by sophisticated enzymes encoded in biosynthetic gene clusters, whereas some reactions proceed without enzymes. These non-enzymatic reactions complicate biosynthetic analysis of NPs and play important roles in diversifying the structure of the products. Therefore, knowledge on the non-enzymatic reactions is important for elucidating the biosynthetic mechanism. This review focuses on non-enzymatic reactions we recently encountered during biosynthetic studies of four types of NPs (viridicatins, Sch210972, lentopeptins, and lentofuranine).

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.