手握强度可预测胰腺癌患者的生存期

IF 1.7 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-21 DOI:10.1097/MPA.0000000000002319
Julia Freckelton, Ashray Rajagopalan, Gregory T Moore, Daniel Croagh
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引用次数: 0

摘要

研究目的胰腺导管腺癌(PDAC)是一种常见的预后不良的癌症,与恶病质的高发病率有关,恶病质是一种由复杂机制导致肌肉萎缩的代谢综合征。除了肌肉量减少外,癌症患者还会出现功能衰退。本研究旨在确定肌肉质量和功能与临床结果,尤其是生存率之间是否存在关联:我们进行了一项前瞻性队列研究,包括2016年3月至2017年12月期间莫纳什卫生院的所有PDAC患者。我们进行了肌少症的身体成分分析和手握力测试。我们构建了Kaplan-Meier曲线,以估计肌无力症和低握力是否与较差的生存率有关:结果:肌无力症与 PDAC 特异性生存率的显著差异无关(log-rank P = 0.60)。然而,与其他患者相比,低握力与 PDAC 特异性生存率显著降低有关(对数秩危险比,1.88;95% 置信区间,1.15-3.09;P = 0.004):PDAC患者的生存率与手握力(而非解剖学肌肉质量)之间的关系表明,除了现有的工具(如东部合作肿瘤学组的表现状态)外,力量功能测试可能对PDAC患者的预后也很重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Handgrip Strength Predicts Survival in Patients With Pancreatic Cancer.

Objectives: Pancreatic ductal adenocarcinoma (PDAC) is a common cancer with a poor prognosis and is associated with a high prevalence of cachexia, a metabolic syndrome of muscle wasting due to complex mechanisms. In addition to loss of muscle mass, cancer patients also experience functional deterioration. The aim of this study is to determine whether there is an association between muscle mass and function and clinical outcomes, particularly survival.

Methods: We performed a prospective cohort study including all patients with PDAC at Monash Health from March 2016 to December 2017. We conducted body composition analysis for myopenia and handgrip strength testing. We constructed Kaplan-Meier curves to estimate whether myopenia and low hand grip strength were associated with poorer survival.

Results: Myopenia was not associated with a significant difference in PDAC-specific survival (log-rank P = 0.60). However, low handgrip strength was associated with significantly worse PDAC-specific survival compared with other patients (log-rank hazard ratio, 1.88; 95% confidence interval, 1.15-3.09; P = 0.004).

Conclusions: The relationship between survival in PDAC and handgrip strength, but not anatomical muscle mass, suggests that functional testing of strength may be important in prognostication of patients with PDAC, alongside existing tools such as the Eastern Cooperative Oncology Group performance status.

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来源期刊
Pancreas
Pancreas 医学-胃肠肝病学
CiteScore
4.70
自引率
3.40%
发文量
289
审稿时长
1 months
期刊介绍: Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.
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