肥胖在先兆子痫发病中的作用。

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Current Hypertension Reports Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI:10.1007/s11906-024-01299-z
Miguel Javier Schiavone, Mariana Paula Pérez, Analía Aquieri, Daniela Nosetto, María Victoria Pronotti, María Mazzei, Cyntia Kudrle, Horacio Avaca
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引用次数: 0

摘要

综述的目的:本综述深入探讨了肥胖与子痫前期(PE)之间的复杂关系,并强调了这种关系的临床意义。它强调了筛查工具在评估个体风险和确定肥胖妇女是否需要额外产前护理方面的关键作用。该综述研究了用于识别子痫前期风险的各种标记物,同时强调了运动、体重管理和均衡饮食等干预措施在降低子痫前期发病率和改善母亲及胎儿预后方面的重要意义:事实上,肥胖在全球范围内流行,尤其是在育龄妇女和孕妇中。以产妇高血压、蛋白尿和并发症为特征的子痫,影响着全球 2%-4% 的孕妇,对产妇和围产期健康构成重大风险。肥胖妇女罹患 PE 的风险较高,这是因为过多的脂肪会导致全身炎症,从而对胎盘发育造成不利影响。脂肪组织富含促炎细胞因子和补体蛋白,可促进母体中抗血管生成因子的表达,从而导致 PE 的发病机制。本综述强调了适当筛查、干预和整体方法的必要性,以降低子痫前期的发病率并提高母胎健康,从而为肥胖与 PE 之间的多方面关联提供了宝贵的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Role of Obesity in the Development of Preeclampsia.

The Role of Obesity in the Development of Preeclampsia.

Purpose of review: This comprehensive review provides an in-depth exploration of the complex relationship between obesity and preeclampsia (PE) and emphasizes the clinical implications of this association. It highlights the crucial role of screening tools in assessing individual risk and determining the need for additional antenatal care among women with obesity. The review investigates various markers for identifying the risk of developing PE, while emphasizing the significance of interventions such as exercise, weight management, and a balanced diet in reducing the incidence of preeclampsia and improving outcomes for both mother and fetus.

Recent findings: Actually, there is a global pandemic of obesity, particularly among women of childbearing age and pregnant women. PE, which is characterized by maternal hypertension, proteinuria, and complications, affects 2-4% of pregnancies worldwide, posing significant risks to maternal and perinatal health. Women with obesity face an elevated risk of developing PE due to the systemic inflammation resulting from excess adiposity, which can adversely affect placental development. Adipose tissue, rich in proinflammatory cytokines and complement proteins, contributes to the pathogenesis of PE by promoting the expression of antiangiogenic factors in the mother. This review emphasizes the need for appropriate screening, interventions, and a holistic approach to reduce the incidence of preeclampsia and enhance maternal-fetal well-being, thus providing valuable insights into the multifaceted association between obesity and PE.

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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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