{"title":"埃博拉病毒传播模型的丰富时空动态:复合发病率函数和与密度无关的治疗方法","authors":"Calvin Tadmon , Jacques Ndé Kengne","doi":"10.1016/j.nonrwa.2024.104118","DOIUrl":null,"url":null,"abstract":"<div><p>In this work, we are concerned with the mathematical modeling and analysis of Ebola virus disease dynamics. Firstly, we design and analyze a nonlinear ordinary differential equations model integrating both direct and indirect transmission pathways with density-independent treatment and a composite nonlinear incidence function. We begin the analysis by proving the global existence of a unique positive and bounded solution. Then we compute the basic reproduction number on which relies the global dynamics of the model. We precisely show the existence of a unique disease-free equilibrium and that of a unique endemic equilibrium, and prove their global stability under appropriate assumptions on the basic reproduction number. Moreover, we perform the global sensitivity analysis of the basic reproduction number to assess the variability in the model predictions. We find that the forecasts closely agree with the 2014 outbreaks of the disease in Liberia and Sierra Leone. Secondly, we enrich this first model by extending it to a partially degenerate reaction–diffusion system via the inclusion of Fickian diffusion for susceptible and non-hospitalized infectious individuals in order to understand the dynamics of the disease transmission in a spatially homogeneous environment. We prove the global stability of the disease-free equilibrium and the uniform persistence when the basic reproduction number lies below and above one, respectively. Finally, numerical simulations are performed to illustrate some theoretical results obtained.</p></div>","PeriodicalId":49745,"journal":{"name":"Nonlinear Analysis-Real World Applications","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enriched spatiotemporal dynamics of a model of Ebola transmission with a composite incidence function and density-independent treatment\",\"authors\":\"Calvin Tadmon , Jacques Ndé Kengne\",\"doi\":\"10.1016/j.nonrwa.2024.104118\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this work, we are concerned with the mathematical modeling and analysis of Ebola virus disease dynamics. Firstly, we design and analyze a nonlinear ordinary differential equations model integrating both direct and indirect transmission pathways with density-independent treatment and a composite nonlinear incidence function. We begin the analysis by proving the global existence of a unique positive and bounded solution. Then we compute the basic reproduction number on which relies the global dynamics of the model. We precisely show the existence of a unique disease-free equilibrium and that of a unique endemic equilibrium, and prove their global stability under appropriate assumptions on the basic reproduction number. Moreover, we perform the global sensitivity analysis of the basic reproduction number to assess the variability in the model predictions. We find that the forecasts closely agree with the 2014 outbreaks of the disease in Liberia and Sierra Leone. Secondly, we enrich this first model by extending it to a partially degenerate reaction–diffusion system via the inclusion of Fickian diffusion for susceptible and non-hospitalized infectious individuals in order to understand the dynamics of the disease transmission in a spatially homogeneous environment. We prove the global stability of the disease-free equilibrium and the uniform persistence when the basic reproduction number lies below and above one, respectively. Finally, numerical simulations are performed to illustrate some theoretical results obtained.</p></div>\",\"PeriodicalId\":49745,\"journal\":{\"name\":\"Nonlinear Analysis-Real World Applications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-03-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nonlinear Analysis-Real World Applications\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1468121824000580\",\"RegionNum\":3,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATHEMATICS, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nonlinear Analysis-Real World Applications","FirstCategoryId":"100","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1468121824000580","RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATHEMATICS, APPLIED","Score":null,"Total":0}
Enriched spatiotemporal dynamics of a model of Ebola transmission with a composite incidence function and density-independent treatment
In this work, we are concerned with the mathematical modeling and analysis of Ebola virus disease dynamics. Firstly, we design and analyze a nonlinear ordinary differential equations model integrating both direct and indirect transmission pathways with density-independent treatment and a composite nonlinear incidence function. We begin the analysis by proving the global existence of a unique positive and bounded solution. Then we compute the basic reproduction number on which relies the global dynamics of the model. We precisely show the existence of a unique disease-free equilibrium and that of a unique endemic equilibrium, and prove their global stability under appropriate assumptions on the basic reproduction number. Moreover, we perform the global sensitivity analysis of the basic reproduction number to assess the variability in the model predictions. We find that the forecasts closely agree with the 2014 outbreaks of the disease in Liberia and Sierra Leone. Secondly, we enrich this first model by extending it to a partially degenerate reaction–diffusion system via the inclusion of Fickian diffusion for susceptible and non-hospitalized infectious individuals in order to understand the dynamics of the disease transmission in a spatially homogeneous environment. We prove the global stability of the disease-free equilibrium and the uniform persistence when the basic reproduction number lies below and above one, respectively. Finally, numerical simulations are performed to illustrate some theoretical results obtained.
期刊介绍:
Nonlinear Analysis: Real World Applications welcomes all research articles of the highest quality with special emphasis on applying techniques of nonlinear analysis to model and to treat nonlinear phenomena with which nature confronts us. Coverage of applications includes any branch of science and technology such as solid and fluid mechanics, material science, mathematical biology and chemistry, control theory, and inverse problems.
The aim of Nonlinear Analysis: Real World Applications is to publish articles which are predominantly devoted to employing methods and techniques from analysis, including partial differential equations, functional analysis, dynamical systems and evolution equations, calculus of variations, and bifurcations theory.