局部芦荟对实验设计的大鼠阴茎骨折模型的影响。

Reha Girgin, Gökhan Çeker, Inci Turan, Filiz Kutu, Yusuf Elma, Emine Yılmaz Can
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引用次数: 0

摘要

背景:本研究评估了局部芦荟(AV)对大鼠阴茎骨折(PF)的组织病理学和氧化作用:本研究评估了局部芦荟(AV)对大鼠实验性阴茎骨折(PF)的组织病理学和氧化作用:方法:使用 40 只 Wistar 白化大鼠(220-250 克)。方法:使用 40 只 Wistar 白化大鼠(220-250 克),用 15 号柳叶刀在实验中制作阴茎骨折模型。然后,将大鼠随机平均分为五组。第一组(C)不做切口。第二组(P)切口。第三组(PR)主要关闭切口线。第四组(PA)在切口局部应用 AV,三天内不缝合。最后一组(PRA)在主要修复区域应用 AV 三天。根据组织病理学和生化数据对各组进行比较:结果:与其他组相比,PRA 组的充血出血得到了抑制(P0.05):结论:局部应用 AV 可减少组织炎症和氧化应激,但似乎会增加 PF 后纤维化的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effects of topical aloe vera on an experimentally designed penile fracture model in rats.

Background: This study assessed the histopathological and oxidative effects of topical Aloe Vera (AV) on penile fractures (PF) formed experimentally in a rat model.

Methods: Forty Wistar albino rats (220-250 g) were used. The PF model was created experimentally with a number 15 lancet. Then, the rats were randomly and equally divided into five groups. In the first group (C), no incision was formed. In the second group (P), an incision was formed. In the third group (PR), the incision line was closed primarily. In the fourth group (PA), AV was locally applied onto the incision without suturing for three days. In the last group (PRA), AV was applied to the primary repair region for three days. All groups were compared to each other according to histopathological and biochemical data.

Results: Hyperemia-bleeding was observed to be suppressed in the PRA group compared to the other groups (p<0.001). Inflammation was observed only in Groups PR and PRA (p<0.001). Significant fibrosis was observed in the PA and PRA groups compared to the other groups (p<0.001). Superoxide Dismutase (SOD) and Glutathione (GSH) values increased in favor of Group PRA (p=0.009 and p=0.035, respectively). Total Oxidative Status (TOS) and Malondialdehyde (MDA) values decreased in favor of Group PA (p=0.036 and p=0.026, respectively). Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-1 beta (IL-1ß) levels decreased mostly in the PRA group, but these changes did not reach statistical significance (p>0.05).

Conclusion: Topical AV application reduces tissue inflammation and oxidative stress but appears to increase the development of fibrosis after PF.

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