脂肪族聚酯中的肽酰化：机制与抑制策略综述

IF 3.5 3区医学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Pharmaceutical Research Pub Date : 2024-03-19 DOI:10.1007/s11095-024-03682-6

Mojgan Sheikhi, Nasrin Nemayandeh, Mehrnoosh Shirangi

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引用次数: 0

摘要

生物降解聚酯广泛应用于多肽药物控释系统的开发。然而，开发基于聚酯的多肽给药系统所面临的挑战之一是多肽与聚合物之间的酰化反应。肽的酰化反应是影响制剂稳定性的一个重要因素，可在储存、体外释放和给药后发生。本综述重点介绍影响聚酯中肽酰化速率的机制和参数。此外，它还讨论了已报道的尽量减少酰化反应的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies

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Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies

Biodegradable polyesters are widely employed in the development of controlled release systems for peptide drugs. However, one of the challenges in developing a polyester-based delivery system for peptides is the acylation reaction between peptides and polymers. Peptide acylation is an important factor that affects formulation stability and can occur during storage, in vitro release, and after drug administration. This review focuses on the mechanisms and parameters that influence the rate of peptide acylation within polyesters. Furthermore, it discusses reported strategies to minimize the acylation reaction.

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来源期刊

Pharmaceutical Research 医学-化学综合

CiteScore

6.60

自引率

5.40%

发文量

276

审稿时长

3.4 months

期刊介绍： Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists, is committed to publishing novel research that is mechanism-based, hypothesis-driven and addresses significant issues in drug discovery, development and regulation. Current areas of interest include, but are not limited to: -(pre)formulation engineering and processing- computational biopharmaceutics- drug delivery and targeting- molecular biopharmaceutics and drug disposition (including cellular and molecular pharmacology)- pharmacokinetics, pharmacodynamics and pharmacogenetics. Research may involve nonclinical and clinical studies, and utilize both in vitro and in vivo approaches. Studies on small drug molecules, pharmaceutical solid materials (including biomaterials, polymers and nanoparticles) biotechnology products (including genes, peptides, proteins and vaccines), and genetically engineered cells are welcome.