{"title":"纳米脂质体颗粒在结直肠癌和卵巢癌治疗中的应用","authors":"Sheikh Rezzak Ali , Chinmoyee Deori , Gaurab Kr Gogoi , Naba Jyoti Borah , Prajnyan Prasad Kalita , Rubina Chowdhury , Simran Kaur , Bibhuti Bhusan Kakoti","doi":"10.1016/j.ejmcr.2024.100149","DOIUrl":null,"url":null,"abstract":"<div><p>Cancer is an expansionist disease, it invades through tissues, sets up colonies in hostile landscapes, seeking “sanctuary” in one organ and then immigrating to another. Ovarian and colorectal cancer has high mortality rates in India. Colorectal cancer typically begins in the gut lining and can spread through the colon wall and beneath the muscular layers, and is a significant source of morbidity. Ovarian cancer has the highest recurrence rate of all gynaecologic cancers and has high mortality because of late diagnosis brought on by vague symptoms. In this review article, we have discussed that apart from the conventional ways of treatment, how nanoparticles has the potential to improve the detection, diagnosis, and treatment of these cancers. Liposomal nanoparticles are lipid-based vesicles that can encapsulate drugs and deliver them to specific targets in the body, potentially improving the effectiveness and reducing the side effects of the treatment. This article also provides an insight on the fact that while liposomal nanoparticles show promising effect, there are challenges to be addressed, including optimizing drug release rates, and ensuring effective targeting.</p></div>","PeriodicalId":12015,"journal":{"name":"European Journal of Medicinal Chemistry Reports","volume":"11 ","pages":"Article 100149"},"PeriodicalIF":0.0000,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772417424000219/pdfft?md5=61db6dafaa09205efd3208fdc22c747f&pid=1-s2.0-S2772417424000219-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Liposomic nano particles in the treatment of colorectal and ovarian cancer\",\"authors\":\"Sheikh Rezzak Ali , Chinmoyee Deori , Gaurab Kr Gogoi , Naba Jyoti Borah , Prajnyan Prasad Kalita , Rubina Chowdhury , Simran Kaur , Bibhuti Bhusan Kakoti\",\"doi\":\"10.1016/j.ejmcr.2024.100149\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cancer is an expansionist disease, it invades through tissues, sets up colonies in hostile landscapes, seeking “sanctuary” in one organ and then immigrating to another. Ovarian and colorectal cancer has high mortality rates in India. Colorectal cancer typically begins in the gut lining and can spread through the colon wall and beneath the muscular layers, and is a significant source of morbidity. Ovarian cancer has the highest recurrence rate of all gynaecologic cancers and has high mortality because of late diagnosis brought on by vague symptoms. In this review article, we have discussed that apart from the conventional ways of treatment, how nanoparticles has the potential to improve the detection, diagnosis, and treatment of these cancers. Liposomal nanoparticles are lipid-based vesicles that can encapsulate drugs and deliver them to specific targets in the body, potentially improving the effectiveness and reducing the side effects of the treatment. This article also provides an insight on the fact that while liposomal nanoparticles show promising effect, there are challenges to be addressed, including optimizing drug release rates, and ensuring effective targeting.</p></div>\",\"PeriodicalId\":12015,\"journal\":{\"name\":\"European Journal of Medicinal Chemistry Reports\",\"volume\":\"11 \",\"pages\":\"Article 100149\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2772417424000219/pdfft?md5=61db6dafaa09205efd3208fdc22c747f&pid=1-s2.0-S2772417424000219-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Medicinal Chemistry Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772417424000219\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Medicinal Chemistry Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772417424000219","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Liposomic nano particles in the treatment of colorectal and ovarian cancer
Cancer is an expansionist disease, it invades through tissues, sets up colonies in hostile landscapes, seeking “sanctuary” in one organ and then immigrating to another. Ovarian and colorectal cancer has high mortality rates in India. Colorectal cancer typically begins in the gut lining and can spread through the colon wall and beneath the muscular layers, and is a significant source of morbidity. Ovarian cancer has the highest recurrence rate of all gynaecologic cancers and has high mortality because of late diagnosis brought on by vague symptoms. In this review article, we have discussed that apart from the conventional ways of treatment, how nanoparticles has the potential to improve the detection, diagnosis, and treatment of these cancers. Liposomal nanoparticles are lipid-based vesicles that can encapsulate drugs and deliver them to specific targets in the body, potentially improving the effectiveness and reducing the side effects of the treatment. This article also provides an insight on the fact that while liposomal nanoparticles show promising effect, there are challenges to be addressed, including optimizing drug release rates, and ensuring effective targeting.