Neu5Gc 可调节蜕膜巨噬细胞，导致胚胎异常着床。

IF 5 3区医学 Q1 GENETICS & HEREDITY

Genes and immunity Pub Date : 2024-03-18 DOI:10.1038/s41435-024-00268-5

Wu Yue, Zhou Huiling, Liu Yuxin, Wang Ling, Gao Feng, Liu Qicai

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引用次数: 0

摘要

反复植入失败（RIF）是辅助生殖领域最突出的问题之一。蜕膜巨噬细胞（dMΦ）表面的Neu5Gc会导致dMΦ的不同活化模式，从而影响胚胎的着床和发育。给体内诱导产生抗Neu5Gc抗体的Cmah-/-（Neu5Gc缺陷）小鼠喂食富含Neu5Gc的特殊食物，并监测其生育能力。长期食用富含 Neu5Gc 的食物会导致雌性小鼠子宫内膜接受能力下降。喂食正常饮食的雌性小鼠的妊娠率为 63.6%（n = 11），平均胚胎数为 9.571 ± 1.272；而喂食富含 Neu5Gc 的饮食的雌性小鼠的妊娠率为 36.4%（n = 11），平均胚胎数为 5.750 ± 3.304。摄入Neu5Gc和产生抗Neu5Gc抗体导致子宫内膜dMΦ极化为M1，胚胎着床异常。

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Neu5Gc regulates decidual macrophages leading to abnormal embryo implantation

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Neu5Gc regulates decidual macrophages leading to abnormal embryo implantation

Repeated implantation failure (RIF) is one of the most prominent problems in the field of assisted reproduction. Neu5Gc on the surface of decidual macrophages (dMΦ) leads to different activation patterns of dMΦ, which affects embryo implantation and development. Cmah−/− (Neu5Gc-deficient) mice induced to produce anti-Neu5Gc antibodies in vivo were given a special diet rich in Neu5Gc and their fertility was monitored. The long-term diet rich in Neu5Gc induced the decrease of endometrial receptivity of female mice. The pregnancy rate of female mice fed the normal diet was 63.6% (n = 11) and the average number of embryos was 9.571 ± 1.272, while the pregnancy rate of female mice fed the diet rich in Neu5Gc was 36.4% (n = 11) and the average number of embryos in pregnant mice was 5.750 ± 3.304. The intake of Neu5Gc and the production of anti-Neu5Gc antibody led to M1 polarization of endometrial dMΦ and abnormal embryo implantation.

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来源期刊

Genes and immunity 医学-免疫学

CiteScore

8.90

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.