研究 PET/CT 扫描显示的影响 CT 衰减和骨髓葡萄糖代谢的因素。

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
American journal of nuclear medicine and molecular imaging Pub Date : 2024-02-20 eCollection Date: 2024-01-01
Shiro Ishii, Ryo Yamakuni, Shigeyasu Sugawara, Junko Hara, Yoshiki Endo, Hirotoshi Hotsumi, Mahori Hiruta, Honami Kobiyama, Yuki Yaginuma, Kenji Fukushima, Hiroshi Ito
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引用次数: 0

摘要

本研究旨在确定影响骨髓 CT 衰减的因素及其与 18F-FDG 摄取的相关性。研究测量了 243 名接受 18F-FDG PET/CT 的患者的椎骨骨髓(Vertebral-SUV)和股骨髓(Femoral-SUV)的平均标准化摄取值(SUV)以及骨髓 CT 数量(BM-CT 数量)。研究了骨髓 CT 数、股骨-SUV 和椎骨-SUV 之间的相关性。通过相关分析和多元回归分析,分析了股骨-SUV、椎骨-SUV 和 BM-CT 数量与血液参数、年龄、血糖和体重的关系。采用曼-惠特尼 U 检验和卡方检验以及二项式逻辑分析来检验高 BM-CT 数量(≥ 0 HU)与上述参数之间的关系。结果表明BM-CT数量与股骨-SUV(r = 0.73,P < 0.01);椎骨-SUV与股骨-SUV(r = 0.78,P < 0.01);BM-CT数量与椎骨-SUV(r = 0.52,P < 0.01)。在单变量分析(r = -0.27)和多变量分析(β = -0.20)中,BM-CT 数量与患者年龄相关。在单变量(P = 0.04)和多变量(P < 0.01)分析中,BM-CT 阳性数量与白细胞相关。骨髓葡萄糖代谢随年龄增长呈下降趋势,CRP升高的患者骨髓葡萄糖代谢增加。总之,骨髓 CT 的衰减与骨髓代谢有很好的相关性,也有随年龄增长而降低的趋势。高骨髓衰减(≥ 0 HU)可预测血清白细胞升高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of factors affecting CT attenuation and glucose metabolism of bone marrow as seen on PET/CT scans.

The aim of this study is to determine the factors affecting the CT attenuation of bone marrow, and its correlation with 18F-FDG uptake. The mean standardized uptake value (SUV) of vertebral bone marrow (Vertebral-SUV) and femoral bone marrow (Femoral-SUV) as well as CT number of bone marrow (BM-CT number) were measured in 243 patients who had undergone 18F-FDG PET/CT. The correlations among BM-CT number, Femoral-SUV, and Vertebral-SUV were investigated. The relationships of Femoral-SUV, Vertebral-SUV, and BM-CT number with blood parameters, age, blood sugar, and body weight were analyzed by correlation and multi-regression analyses. The Mann-Whitney U test and chi-square test and Binomial logistic analysis were used to examine the relationships between high BM-CT number (≥ 0 HU) and the above parameters. Significant correlations were observed between: BM-CT number and Femoral-SUV (r = 0.73, P < 0.01); Vertebral-SUV and Femoral-SUV (r = 0.78, P < 0.01); and BM-CT number and Vertebral-SUV (r = 0.52, P < 0.01). BM-CT number was correlated with patients' age in both univariable (r = -0.27) and multivariable analyses (β = -0.20). Positive BM-CT number correlated with WBC in both univariable (P = 0.04) and multivariable (P < 0.01) analyses. Bone marrow glucose metabolism had a tendency to decrease with age, was increased in patients with elevated CRP. In conclusion, CT attenuation of bone marrow correlated well with bone marrow metabolism and also tended to decrease with age. High bone marrow attenuation (≥ 0 HU) could predict elevated serum WBC.

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来源期刊
American journal of nuclear medicine and molecular imaging
American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
自引率
4.00%
发文量
4
期刊介绍: The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.
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