功能性无精子症中 B 抑制素和抗苗勒氏管激素的估计及其与手术取精的相关性:前瞻性病例对照研究。

IF 0.8 Q4 UROLOGY & NEPHROLOGY
Urologia Journal Pub Date : 2024-08-01 Epub Date: 2024-03-15 DOI:10.1177/03915603241235716
Sameh Fayek GamalEl Din, Nashaat Nabil, Hanan Hosni Moawad, Medhat Amer, Wael Zohdy, Abdel Rahman Bakry, Martina Tharwat Raoof, Asmaa Mohammed, Yasser Salem
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引用次数: 0

摘要

研究目的本研究评估了非梗阻性无精子症(NOA)和梗阻性无精子症(OA)病例中抗苗勒氏管激素(AMH)和抑制素-B以及生殖激素的水平,并比较了它们在确定NOA病例取精希望方面的敏感性和特异性。最后,我们分析了本次研究中测量的所有激素之间的潜在相关性:本病例对照研究于 2021 年 6 月至 2022 年 3 月在泌尿科门诊进行。研究招募了 135 名参与者,将其平均分为三组,分别是 NOA 病例、OA 病例和对照组:结果:NOA病例的平均抑制素-B明显低于OA病例和对照组。AMH和抑制素-B之间呈中度正相关。此外,抑制素-B与游离睾酮(FT)呈中度正相关,β抑制素与促卵泡生成素(LH)呈弱正相关:目前的研究证实,抑制素-B 也能在 Leydig 细胞中表达,因为它与 FT 和 LH 呈正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimation of B-inhibin and anti mullerian hormone in functional azoospermia and their correlations with surgical sperm retrieval: A prospective case-control study.

Objectives: The current study estimated the levels of anti mullerian hormone (AMH) and inhibin-B and reproductive hormones in non obstructive azoospermic (NOA) cases and obstructive azoospermic (OA) cases as well as comparing between them as regards the sensitivity and specificity in determining the sperm retrieval hope in the NOA cases. Finally, we analyzed any potential correlation between all the hormones measured in the current study.

Methods: The current case control study was conducted at the andrology outpatient clinic from June (2021) to March (2022). The study recruited 135 participants divided equally into three groups NOA cases, OA cases and controls, respectively.

Results: The mean inhibin-B was significantly lower in the NOA cases compared to the OA cases and the controls. There was a positive moderate correlation between AMH and Inhibin-B. Also, there was a positive moderate correlation between inhibin-B and free testosterone (FT) and positive weak correlation between beta Inhibin and leutinizing hormone (LH).

Conclusions: The current study asserts the observation that inhibin-B is also expressed by Leydig cells as it has demonstrated positive correlations with FT and LH.

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来源期刊
Urologia Journal
Urologia Journal UROLOGY & NEPHROLOGY-
CiteScore
0.60
自引率
12.50%
发文量
66
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