一种丝氨酸代谢酶正在发挥它的作用，帮助修复骨骼肌。

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2024-03-22 DOI:10.1101/gad.351666.124

Benjámin R Baráth, Laszlo Nagy

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引用次数: 0

摘要

干细胞的代谢重编程是控制再生的一个目标途径。干细胞激活会导致氧化磷酸化（OXPHOS）和脂肪酸氧化（FAO）下调，并开启糖酵解，为增殖和特定信号事件提供燃料。细胞类型特异性事件是如何调节的尚不清楚。在本期《基因与发育》（Genes & Development）杂志上，Ciuffoli及其同事（第XXX-XXX页）利用代谢组学、基因失活和功能方法证明，丝氨酸生物合成中的一种酶--磷酸丝氨酸氨基转移酶（Psat1）在肌肉干细胞中被激活，并通过产生α-酮戊二酸和谷氨酰胺促进细胞扩增和骨骼肌再生。

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A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle.

Metabolic reprogramming of stem cells is a targetable pathway to control regeneration. Activation of stem cells results in down-regulation of oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) and turns on glycolysis to provide fuel for proliferation and specific signaling events. How cell type-specific events are regulated is unknown. In this issue of Genes & Development Ciuffoli and colleagues (pp. 151-167) use metabolomic, gene inactivation, and functional approaches to show that phosphoserine aminotransferase (Psat1), an enzyme in serine biosynthesis, is activated in muscle stem cells and contributes to cell expansion and skeletal muscle regeneration via the production of α-ketoglutarate and glutamine.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).