{"title":"维生素 D 结合蛋白变异与主要膳食模式对表面健康成年人心理健康状况的相互作用","authors":"Yasaman Nasir , Atiyeh Niknam , Mohammad Hossein Rahimi , Mahdi Molahosseini , Khadijeh Mirzaei","doi":"10.1016/j.eujim.2024.102352","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Recent studies have shown that the risks of mental disorders resulting from vitamin D deficiency, such as depression, anxiety and stress, can be affected by various high-risk alleles. Among the genes interacting with environmental factors are those associated with vitamin D binding protein (DBP) that affects the status of 25- OH vitamin D. Therefore, the present study aimed to determine the interaction between dietary patterns and <em>DBP</em> gene variants on mental health status in adults.</p></div><div><h3>Methods</h3><p>This cross-sectional study was conducted on a random sample of adult participants (<em>n</em> = 265 and 18–55 years old) in Tehran. Major dietary patterns were determined using principal component analysis (PCA) method on 24 food groups, using a valid and reliable 147-item food frequency questionnaire (FFQ). <em>DBP</em> genotypes were determined by polymerase chain reactions - restriction fragment length polymorphism (PCR-RFLP). Data about the mental health status were collected using the Depression, Anxiety, Stress Score (DASS-21).</p></div><div><h3>Results</h3><p>Results demonstrated strong interactions between higher adherence to healthy dietary patterns in individuals with the major allele (low-risk allele) carriers of rs7041 (GG genotype), in relation to reduced stress score (OR= -2.54, 95 % CI = -4.60 to -0.48, P interaction = 0.02). Also, individuals with higher adherence to healthy dietary patterns with GG genotype of rs7041 indicated reduced stress score, but it was not significant (OR = -1.84, 95 % CI = 0.18 to -3.86, P interaction = 0.07).</p></div><div><h3>Conclusion</h3><p>The present evidence indicates that interactions between healthy dietary patterns with <em>DBP</em> variants (rs7041 - GG genotype) may effectively reduce the odds of mental disorders , especially in stress, through consuming healthy food groups and inherited low-risk alleles.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"67 ","pages":"Article 102352"},"PeriodicalIF":1.9000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Interactions between vitamin D binding protein variants and major dietary patterns on mental health status in apparently healthy adults\",\"authors\":\"Yasaman Nasir , Atiyeh Niknam , Mohammad Hossein Rahimi , Mahdi Molahosseini , Khadijeh Mirzaei\",\"doi\":\"10.1016/j.eujim.2024.102352\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Recent studies have shown that the risks of mental disorders resulting from vitamin D deficiency, such as depression, anxiety and stress, can be affected by various high-risk alleles. 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引用次数: 0
摘要
最近的研究表明,因缺乏维生素 D 而导致精神障碍(如抑郁、焦虑和压力)的风险会受到各种高风险等位基因的影响。因此,本研究旨在确定膳食模式和基因变异对成人精神健康状况的相互作用。这项横断面研究是对德黑兰的成年参与者(n=265,18-55 岁)进行随机抽样的。使用有效可靠的 147 项食物频率问卷(FFQ),采用主成分分析法(PCA)确定了 24 种食物的主要饮食模式。通过抑郁、焦虑、压力评分(DASS-21)收集有关心理健康状况的数据。结果表明,rs7041 的主等位基因(低风险等位基因)携带者(GG 基因型)坚持健康饮食模式的程度越高,压力得分越低(OR= -2.54,95% CI = -4.60 至 -0.48,P 交互作用 = 0.02)。此外,rs7041 基因型为 GG 的个体对健康饮食模式的坚持程度越高,压力得分越低,但并不显著(OR = -1.84, 95% CI = 0.18 to -3.86,P 交互作用 = 0.07)。目前的证据表明,健康饮食模式与变异体(rs7041 - GG 基因型)之间的相互作用可通过摄入健康的食物组和遗传低风险等位基因有效降低精神障碍的几率,尤其是压力。
Interactions between vitamin D binding protein variants and major dietary patterns on mental health status in apparently healthy adults
Introduction
Recent studies have shown that the risks of mental disorders resulting from vitamin D deficiency, such as depression, anxiety and stress, can be affected by various high-risk alleles. Among the genes interacting with environmental factors are those associated with vitamin D binding protein (DBP) that affects the status of 25- OH vitamin D. Therefore, the present study aimed to determine the interaction between dietary patterns and DBP gene variants on mental health status in adults.
Methods
This cross-sectional study was conducted on a random sample of adult participants (n = 265 and 18–55 years old) in Tehran. Major dietary patterns were determined using principal component analysis (PCA) method on 24 food groups, using a valid and reliable 147-item food frequency questionnaire (FFQ). DBP genotypes were determined by polymerase chain reactions - restriction fragment length polymorphism (PCR-RFLP). Data about the mental health status were collected using the Depression, Anxiety, Stress Score (DASS-21).
Results
Results demonstrated strong interactions between higher adherence to healthy dietary patterns in individuals with the major allele (low-risk allele) carriers of rs7041 (GG genotype), in relation to reduced stress score (OR= -2.54, 95 % CI = -4.60 to -0.48, P interaction = 0.02). Also, individuals with higher adherence to healthy dietary patterns with GG genotype of rs7041 indicated reduced stress score, but it was not significant (OR = -1.84, 95 % CI = 0.18 to -3.86, P interaction = 0.07).
Conclusion
The present evidence indicates that interactions between healthy dietary patterns with DBP variants (rs7041 - GG genotype) may effectively reduce the odds of mental disorders , especially in stress, through consuming healthy food groups and inherited low-risk alleles.
期刊介绍:
The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education.
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The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.