化学免疫疗法组合：将基础知识转化为临床成功。

IF 5 3区医学 Q1 GENETICS & HEREDITY

Genes and immunity Pub Date : 2024-03-13 DOI:10.1038/s41435-024-00264-9

Lionel Apetoh

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引用次数: 0

摘要

尽管化疗药物长期以来只与免疫抑制有关，但临床数据表明，某些化疗药物与免疫调节剂的联合使用可对癌症产生益处。然而，如何确定具有最佳抗癌活性和最小毒性的组合仍然是一项重大挑战。临床证据表明，接受联合疗法治疗的患者的免疫反应与无进展生存期有关。对化疗后抗癌免疫反应机制的认识取得了进展，这有助于将相关的化疗免疫疗法组合应用于临床。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemoimmunotherapy combinations: translating basic knowledge into clinical successes

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Chemoimmunotherapy combinations: translating basic knowledge into clinical successes

While chemotherapeutic agents were long solely associated with immunosuppression, clinical data demonstrate that the combination of some chemotherapies with immunomodulators can be beneficial against cancer. Defining combinations featuring optimal anticancer activity along with minimal toxicity remains however a major challenge. Clinical evidence suggests that immune responses in patients treated with combination therapies are associated with progression-free survival. Progress in understanding the mechanisms responsible for anticancer immune responses following chemotherapy administration facilitated the translation of relevant chemoimmunotherapy combinations in the clinic.

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来源期刊

Genes and immunity 医学-免疫学

CiteScore

8.90

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.