例外证明规则--贝达喹啉敏感性的历史回顾。

IF 10.4 1区生物学 Q1 GENETICS & HEREDITY

Genome Medicine Pub Date : 2024-03-13 DOI:10.1186/s13073-024-01311-w

Paolo Miotto, Daniela M Cirillo, Thomas Schön, Claudio U Köser

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引用次数: 0

摘要

在随附的研究中，Nimmo及其同事估算了3500多个地理位置不同的结核分枝杆菌基因组中mmpR5（Rv0678）基因突变的出现日期，该基因是抗结核药物贝达喹啉最重要的耐药基因。这为改进临床试验的设计和分析以及世界卫生组织的耐药性突变目录（解释基因型抗菌药敏感性测试结果的全球参考）提供了重要的启示。

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The exceptions that prove the rule-a historical view of bedaquiline susceptibility.

In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis genomes. This provided important insights to improve the design and analysis of clinical trials, as well as the World Health Organization catalogue of resistance mutations, the global reference for interpreting genotypic antimicrobial susceptibility testing results.

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来源期刊

Genome Medicine GENETICS & HEREDITY-

CiteScore

20.80

自引率

0.80%

发文量

128

审稿时长

6-12 weeks

期刊介绍： Genome Medicine is an open access journal that publishes outstanding research applying genetics, genomics, and multi-omics to understand, diagnose, and treat disease. Bridging basic science and clinical research, it covers areas such as cancer genomics, immuno-oncology, immunogenomics, infectious disease, microbiome, neurogenomics, systems medicine, clinical genomics, gene therapies, precision medicine, and clinical trials. The journal publishes original research, methods, software, and reviews to serve authors and promote broad interest and importance in the field.