抗肥胖药物:当前和未来印度肥胖症治疗方案概览:糖尿病与内分泌综合研究院(IDEA)2023 年大会更新。

IF 3.6 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Subir Ray, Nitin Kapoor, Neeta Deshpande, Sanjay Chatterjee, Janardanan Kumar, Om Tantia, Ghanshyam Goyal, Jagat Jyoti Mukherjee, Awadhesh Kumar Singh
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引用次数: 0

摘要

简介:随着新型抗肥胖药物(AOMs)的快速问世,我们有必要制定一份简明扼要的最新临床实践文件,以帮助繁忙的临床医生进行日常临床实践。在 2023 年糖尿病和内分泌综合学会大会(IDEACON,2023 年 7 月,印度加尔各答)期间,一组代谢内科医生、糖尿病专家、内分泌专家和减肥外科医生汇聚一堂,汇编了印度肥胖症患者药物治疗方案的最新进展:在不同领域的专家对文献进行广泛审阅后,本更新版提供了有关肥胖症管理的所有可用信息,并特别强调了肥胖症患者目前可用和即将上市的 AOMs:专家观点:几种较新的AOMs已被证明能显著减轻体重,因此有望在肥胖症治疗方面实现模式转变。虽然在随机对照试验中,与这些AOMs相关的耐受性和主要不良反应似乎是可以接受的,但由于缺乏足够的长期研究,因此在实际环境中进行药物警戒至关重要。这些药物的易得性和可负担性是另一个值得关注的问题,尤其是在印度等发展中国家。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An overview of therapeutic options of obesity management in India: the Integrated Diabetes and Endocrinology Academy (IDEA) 2023 Congress update.

Introduction: With newer anti-obesity medications (AOMs) being introduced at a rapid pace, it is prudent to make a concise and updated clinical practice document that may help busy clinicians in daily clinical practice. A group of metabolic physicians, diabetologists, endocrinologists, and bariatric surgeons assembled during the Integrated Diabetes and Endocrine Academy 2023 Congress (IDEACON, July 2023, Kolkata, India) to compile an update of pharmacotherapeutic options for managing people with obesity in India.

Areas covered: After an extensive review of the literature by experts in different domains, this update provides all available information on the management of obesity, with a special emphasis on both currently available and soon-to-be-available AOMs, in people with obesity.

Expert opinion: Several newer AOMs have been shown to reduce body weight significantly, thus poised to make a paradigm shift in the management of obesity. While the tolerability and key adverse events associated with these AOMs appear to be acceptable in randomized controlled trials, pharmacovigilance is vital in real-world settings, given the absence of sufficiently long-term studies. The easy availability and affordability of these drugs is another area of concern, especially in developing countries like India.

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来源期刊
Expert Review of Clinical Pharmacology
Expert Review of Clinical Pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
7.30
自引率
2.30%
发文量
127
期刊介绍: Advances in drug development technologies are yielding innovative new therapies, from potentially lifesaving medicines to lifestyle products. In recent years, however, the cost of developing new drugs has soared, and concerns over drug resistance and pharmacoeconomics have come to the fore. Adverse reactions experienced at the clinical trial level serve as a constant reminder of the importance of rigorous safety and toxicity testing. Furthermore the advent of pharmacogenomics and ‘individualized’ approaches to therapy will demand a fresh approach to drug evaluation and healthcare delivery. Clinical Pharmacology provides an essential role in integrating the expertise of all of the specialists and players who are active in meeting such challenges in modern biomedical practice.
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