基于 miRNA 的全基因组甲基化分析构建肝细胞癌的预后模型。

IF 3 4区 医学 Q2 GENETICS & HEREDITY
Epigenomics Pub Date : 2024-03-13 DOI:10.2217/epi-2023-0365
Zhaoqi Shi, Xiaolong Liu, Duguang Li, Xiaoxiao Fan, Lifeng He, Daizhan Zhou, Hui Lin
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引用次数: 0

摘要

目的:利用 miRNA 基因的甲基化水平建立肝细胞癌(HCC)患者的预后模型。材料与方法:通过最小绝对缩减和选择算子以及多变量 Cox 回归分析建立预后模型。选择模型中的一个 miRNA 进行验证。结果利用八个 miRNA 建立了一个预后模型。在160个HCC组织中发现了miR-223的低甲基化,其甲基化水平与巴塞罗那临床肝癌分期和HCC患者的预后有关。结论基于 miRNA 甲基化水平的预后模型能够部分预测 HCC 患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Construction of a prognostic model based on genome-wide methylation analysis of miRNAs for hepatocellular carcinoma.

Aim: Using the methylation level of miRNA genes to develop a prognostic model for patients with hepatocellular carcinoma (HCC). Materials & methods: least absolute shrinkage and selection operator and multivariate Cox regression analyses were performed to develop a prognostic model. One miRNA in the model was selected for verification. Results: A prognostic model was developed using eight miRNAs. The areas under the curve for predicting overall survival at 1, 3 and 5 years were 0.75, 0.81 and 0.81. miR-223 was found to be hypomethylated in 160 HCC tissues, and its methylation level was associated with Barcelona Clinic Liver Cancer stages and the prognosis of patients with HCC. Conclusion: The prognostic model based on miRNA methylation levels has the capability to partially forecast the prognosis of patients with HCC.

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来源期刊
Epigenomics
Epigenomics GENETICS & HEREDITY-
CiteScore
5.80
自引率
2.60%
发文量
95
审稿时长
>12 weeks
期刊介绍: Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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