4 甲基吡啶 N-氧化物有机催化的醇类无胺 O-磷酸化反应

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2024-03-12 DOI:10.1248/cpb.c24-00029

Keisuke Yoshida, Wataru Hirano, Ryuuki Ota, Shinji Kitagaki

引用次数: 0

摘要

在室温下，在 4 Å 分子筛的存在下，利用 4-甲基吡啶 N-氧化物开发了各种醇的无胺磷酸化。这种温和的方法能高产率地得到各种磷酸化产物，并可用于对酸或碱敏感的底物。此外，这种方法对于二元醇或多元醇的化学选择性磷酸化也很有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Organocatalyzed Amine-Free O-Phosphorylation of Alcohols with 4-Methylpyridine N-Oxide

Amine-free phosphorylation of various alcohols was developed with 4-methylpyridine N-oxide in the presence of 4 Å molecular sieves at room temperature. This mild method gave various phosphorylated products in high yield and could be applied to acid- or base-sensitive substrates. Furthermore, this method was also effective for the chemoselective phosphorylation of diols or polyols.

Fullsize Image

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.