他汀类药物对巨噬细胞极化的调节作用:机理和治疗意义。

IF 2.8 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Mahvash Sadeghi, Shaho Khayati, Sajad Dehnavi, Wael Almahmeed, Vasily N Sukhorukovi, Amirhossein Sahebkar
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引用次数: 0

摘要

他汀类药物又称 HMG-CoA 还原酶抑制剂,是预防和治疗心血管疾病的广泛处方药。除了降脂作用外,这些化合物还具有免疫调节特性。巨噬细胞是人体内重要的吞噬细胞,可分为两大亚群:M1(促炎)和 M2(抗炎)。有证据表明,他汀类药物对巨噬细胞具有抗炎作用,并促进其向 M2 亚群极化,但最近的研究发现,他汀类药物对巨噬细胞具有促炎作用,导致其向 M1 亚群极化。例如,他汀类药物可抑制 NF-κB 的激活,从而促进抗炎反应。另一方面,他汀类药物可诱导巨噬细胞中 NFκB/AP-1 的活化并增加 IL-1β 的分泌,从而促进促炎反应。本综述旨在全面概述他汀类药物对各种疾病中巨噬细胞极化和炎症反应影响的体内和体外研究。此外,本综述还试图评估这些影响所涉及的潜在机制。通过总结现有证据,本综述有助于我们了解他汀类药物与巨噬细胞在不同疾病中的复杂相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulatory impact of statins on macrophage polarization: mechanistic and therapeutic implications.

Statins, also known as HMG-CoA reductase inhibitors, are widely prescribed drugs for the prevention and treatment of cardiovascular diseases. In addition to their lipid-lowering effects, these compounds have been found to possess immune-modulating properties. Macrophages, which are crucial phagocytic cells in the body, can be divided into two main subsets: M1 (proinflammatory) and M2 (anti-inflammatory). While there is evidence suggesting that statins exert an anti-inflammatory action on macrophages and promote their polarization towards the M2 subset, recent studies have identified the proinflammatory impact of statins on macrophages, leading to polarization towards the M1 subset. For example, statins have been shown to inhibit NF-κB activation to promote anti-inflammatory responses. On the other hand, statins can induce NFκB/AP-1 activation and increase IL-1β secretion in macrophages to promote pro-inflammatory responses. This review aims to provide a comprehensive overview of both in vivo and in vitro studies that have investigated the effects of statins on macrophage polarization and inflammatory responses in various diseases. Furthermore, this review seeks to evaluate the underlying mechanisms involved in these effects. By summarizing the existing evidence, this review contributes to our understanding of the complex interactions between statins and macrophages in different disease contexts.

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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
91
审稿时长
3 months
期刊介绍: JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.
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