培养细胞中基于效应的方法--检测饮用水中化学危害的宝贵工具

WIREs Water Pub Date : 2024-03-10 DOI:10.1002/wat2.1730
Johan Lundqvist, Agneta Oskarsson
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引用次数: 0

摘要

饮用水的化学污染是公众健康的重大问题。化学分析用于监测选定的化学物质,但无法获得水样中未知化学物质或化学混合物潜在毒性的信息。基于细胞效应的方法是一种新的高通量工具,可用于评估饮用水中存在的整个化学品混合物的危害。这些方法可与化学分析一起用于评估饮用水的化学安全性。本文将回顾在细胞中采用基于效应的方法的原理,以及这些方法与传统的化学分析方法和在整个生物体中采用基于效应的方法的比较。此外,本文还将列举文献中的实例,强调如何在不同的实际应用中使用基于细胞效应的方法来提高饮用水的安全性;例如,用于监测饮用水水质和评估饮用水处理过程中的处理效率。最后,本文将回顾目前监管机构和水务部门对这些方法的接受程度,并讨论基于效应的方法在改善饮用水安全方面的作用的未来预期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect-based methods in cultured cells—Valuable tools for detection of chemical hazards in drinking water

Effect-based methods in cultured cells—Valuable tools for detection of chemical hazards in drinking water
Chemical contamination of drinking water is of great concern for public health. Chemical analyses are used for monitoring of selected chemicals, however, no information on unknown chemicals or potential toxicity of the mixture of chemicals in a water sample is obtained. Effect-based methods in cells are new high throughput tools, to evaluate the hazard of the whole mixture of chemicals present in drinking water. These methods can be used together with chemical analysis for assessment of the chemical safety of drinking water. This article will review the principle of effect-based methods in cells and how they compare to traditionally used chemical analysis and effect-based methods in whole organisms. Further, this article will give examples from the literature, highlighting how cellular effect-based methods can be used in different practical applications to improve drinking water safety; for example, for monitoring of drinking water quality and evaluation of treatment efficiency in drinking water processing. Finally, this article will review the current regulatory and water sector acceptance of these methods and discuss future expectations on the role of effect-based methods for improved drinking water safety.
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